黑色素瘤中细胞凋亡抑制蛋白Survivin和MEF2D的表达及意义  

Expressions of apoptosis inhibitor proteins Survivin and MEF2D in melanoma and significance

作　　者：王萍 陆捷洁 Ping Wang;Jie-jie Lu(Department of Dermatology,Hainan Skin Disease Hospital,Haikou,Hainan 570206,China)

机构地区：[1]海南省皮肤病医院皮肤科,海南海口570206

出　　处：《中国现代医学杂志》2019年第2期33-37,共5页China Journal of Modern Medicine

摘　　要：目的探究凋亡抑制蛋白Survivin和MEF2D在黑色素瘤中的表达及其相关性。方法临床收集21例黑色素瘤组织和10例皮内痣组织。使用免疫组织化学和Western blotting检测不同组织中的Survivin和MEF2D蛋白表达水平,并探讨Survivin和MEF2D表达的相关性。结果 Survivin和MEF2D在黑色素瘤组织中阳性表达率高于皮内痣组织(P<0.05);Survivin、MEF2D与病理分级有相关性(P<0.05);Western blotting检测发现Survivin和MEF2D在黑色素瘤组织中的表达高于皮内痣组织(P<0.05);Survivin与MEF2D蛋白呈正相关(P <0.05)。结论 Survivin和MEF2D在黑色素瘤组织中高表达,且与病理分级有相关性,MEF2D可能通过调节Survivin表达调控黑色素瘤凋亡,是黑色素瘤发生、发展的重要机制。Objective To explore the expressions of anti-apoptosis proteins Survivin and MEF2D in melanoma and their correlation.Methods The expressions of Survivin and MEF2D were detected in 21 cases of melanoma tissues and 10 cases of intradermal nevus tissues by immunohistochemistry and Western blot.Then the correlation between Survivin and MEF2D expressions was explored.Results The positive rates of Survivin and MEF2D in the melanoma tissues were significantly higher than those in the intradermal nevus tissues(P<0.05).The expressions of Survivin and MEF2D were associated with pathological stage(P<0.05).The expressions of Survivin and MEF2D in melanoma were higher those in the intradermal nevus tissues(P<0.05).Survivin was positively correlated with the expression of MEF2D(P<0.05).Conclusions Survivin and MEF2D are highly expressed in melanoma,and correlated with pathological stage.MEF2D might regulate the expression of Survivin to control the apoptosis of melanoma,and it plays a significant role in the development of melanoma.

关 键 词：黑色素瘤 Survivin/蛋白 MEF2D/蛋白 

分 类 号：R739.5[医药卫生—肿瘤]