fPSA、tPSA及f/tPSA对前列腺癌患者的临床诊断效果研究  

Clinical Diagnostic Effect of f PSA,t PSA and f/t PSA on Patients with Prostate Cancer

作　　者：赖秀梅[1] 沈宗坤[1] 张娜 LAI Xiumei;SHEN Zongkun;ZHANG Na(Fuxin Central Hospital,Fuxin,23000)

机构地区：[1]辽宁省阜新市中心医院,123000

出　　处：《实用癌症杂志》2019年第1期58-60,共3页The Practical Journal of Cancer

摘　　要：目的研究fPSA、tPSA及f/tPSA对前列腺癌患者的临床诊断效果。方法选择81例前列腺癌患者为前列腺癌组,72例前列腺良性疾病患者为良性前列腺增生组,以及同期进行体检的70例健康男性为健康对照组。检测3组研究对象的血清前列腺特异性抗原(PSA)水平。结果良性前列腺增生组患者的fPSA、tPSA及f/tPSA水平明显高于健康对照组(P <0.05),前列腺癌组患者的血清fPSA、tPSA水平明显高于良性前列腺增生组和健康对照组(P <0.05),f/tPSA水平明显低于良性前列腺增生组和健康对照组(P <0.05);前列腺癌组患者与良性前列腺增生合并尿路感染、急性尿潴留、前列腺炎以及无合并症患者的fPSA、tPSA及f/tPSA水平相比具有明显差异(P <0.05),良性前列腺增生合并尿路感染、急性尿潴留、前列腺炎的fPSA、tPSA水平明显高于无合并症患者(P <0.05),f/tPSA水平明显低于无合并症患者(P <0.05)。结论 fPSA、tPSA及f/tPSA水平对前列腺癌患者的临床具有较高的指导意义。Objective To investigate the clinical diagnostic effect of fPSA,tPSA and f/tPSA on patients with prostate cancer. Methods Selected 81 cases of patients with prostate cancer who were treated as prostate cancer group,72 cases of benign prostatic disease were benign prostatic hyperplasia,and 70 healthy men who were examined in our hospital for the same period were healthy control group.Serum prostate specific antigen (PSA) levels were detected in three groups of subjects. Results fPSA,tPSA and f/tPSA in benign prostatic hyperplasia group were significantly higher than those in healthy control group ( P < 0.05), serum fPSA and tPSA in prostate cancer group were higher than those of benign prostatic hyperplasia group and healthy control group ( P <0.05),f/tPSA was significantly lower than that of benign prostatic hyperplasia group and healthy control group ( P <0.05);fPSA,tPSA and f/tPSA in prostate cancer patients and benign prostatic hyperplasia complicated with urinary tract infection,acute urinary retention,prostatitis and no complications patients had significant difference ( P <0.05),benign prostatic hyperplasia complicated with urinary tract infection,acute urinary retention,prostatitis,fPSA and tPSA were significantly higher than in patients without complications( P <0.05).F/tPSA was significantly lower than that in patients without complications ( P < 0.05). Conclusion FPSA,tPSA and f/tPSA have high guiding significance for the diagnostic of prostate cancer patients.

关 键 词：前列腺特异性抗原 前列腺癌 鉴别诊断 

分 类 号：R737.25[医药卫生—肿瘤]