人非小细胞肺癌中TSG101蛋白、MDM2蛋白及突变型P53蛋白的表达  

Expression of TSG101,MDM2 and mutant P53 proteins in human non-small-cell lung cancer

作　　者：徐艳 曾子华 XU Yan;ZENG Zihua(Department of Pathology,The First People's Hospital of Jinzhou,Dalian 116100,China;Houston Methodist Research Institute,Cancer Pathology Laboratory,Houston Methodist Hospital)

机构地区：[1]大连市金州区第一人民医院病理科,辽宁大连116100 [2]美国德克萨斯州休斯敦卫理公会医院研究所肿瘤病理实验室

出　　处：《沈阳医学院学报》2019年第1期33-35,38,共4页Journal of Shenyang Medical College

摘　　要：目的:探讨TSG101蛋白的表达与肺癌发生发展的关系。方法:采用免疫组化方法评估71例非小细胞肺癌标本中TSG101蛋白、MDM2蛋白、突变型P53蛋白的表达水平。结果:肺癌组TSG101蛋白的表达水平显著低于对照组(P<0.01);突变型P53蛋白全阴肺癌组织中TSG101蛋白与MDM2蛋白的表达水平具有相关性。结论:TSG101蛋白的低表达可能与非小细胞肺癌的发生发展有关。Objective:To explore the relationshiPbetween the expression of TSG101 protein and the occurrence and development of lung cancer.Method:The expression of TSG101,MDM2 and mutant P53 proteins in 71 cases of non-small cell lung cancer tissues were evaluated by immunohistochemical method,and the results were analyzed and compared with SPSS 17.0 software.Results:The expression level of TSG101 in lung cancer grouPwas significantly lower than that in control grouP(P<0.01).The expression of TSG101 and MDM2 showed a positive correlation in the mutant P53-negative lung cancer.Conclusion:The low expression of TSG101 protein may be related to the occurrence and development of non-small cell lung cancer.

关 键 词：非小细胞肺癌 TSG101 MDM2 P53 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]