16排移动CT脑灌注成像的初步结果报告  

Preliminary results of 16-slices mobile CT perfusion imaging for the brain

作　　者：张志强[1] 王振方 王海峰[3] 李飞[1] 丁柏匀 代秋声 徐如祥[1] Zhang Zhiqiang;Wang Zhenfang;Wang Haifeng;Li Fei;Ding Boyun;Dai Qiusheng;Xu Ruxiang(Affiliated BaYi Brain Hospital,the Seventh Medical Center,Chinese PLA General Hospital,Beijing 100700,China;Jiangsu Mokoto Medical Technology Co. Ltd.,Suzhou 215123,China;Department of Neurotrauma,First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]解放军总医院第七医学中心原附属八一脑科医院,北京100700 [2]江苏摩科特医疗科技有限公司,苏州215123 [3]吉林大学第一医院神经创伤外科,长春130021

出　　处：《中华脑科疾病与康复杂志（电子版）》2018年第1期29-32,共4页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

基　　金：全军十二五军事医学重点课题（BWS12J010）;国家自然基金青年科学基金（81100971）

摘　　要：目的应用16排移动CT建立一种脑灌注成像(CTPI)的新方法,评定该扫描仪CTPI成像的可行性和初步应用效果。方法筛选经CT或MRI扫描确定有脑缺血性卒中改变的6例受检者。先经肘静脉高压团注非离子型造影剂100 mL,注射速度2.3 mL/s。应用16排移动CT对确定的感兴趣区行连续动态扫描CTPI成像,扫描条件为扫描管电压120 kV,管电流8 mA,层厚1.1 mm,层间距4.4 mm。采用高级影像处理软件Anythink及去卷积法算法,分别计算病侧感兴趣区和健康侧相对应区的脑血流量(CBF)、脑血容量(CBV)、对比剂平均通过时间(MTT)和达峰时间(TTP)。结果 16排移动CT进行连续动态扫描CTPI检查的成像效果及图像质量符合临床诊断标准。6例受检者CTPI检测数据经统计学分析发现,病侧感兴趣区的CBF(25.226±6.458)mL·100 g^-1·min^-1、CBV(2.756±0.734)mL/100 g、MTT(3.365±1.450)s和TTP(22.314±4.884)s与健康侧相对应区的CBF(29.672±8.879)mL·100 g^-1·min^-1、CBV(3.714±0.401)mL/100 g、MTT(1.730±0.807)s及TTP(22.424±5.395)s相比较,差异无统计学意义(P>0.05)。结论成功建立了16排移动CTPI检查新方法,成像性能良好,CTPI检测计算数据可靠。Objective To evaluate the feasibility and preliminary application effect of CT perfusion imaging (CTPI) of the scanner for patients with ischemic stroke by 16-slices of mobile CT scanner. Methods Six patients with the ischemic stroke identified by CT or MRI scanning were selected in the trial. Firstly, the patient received an injection of 100 mL of non-ionic contrast through elbow vein high-pressure with a speed of 2.3 mL/s. The 16-slices mobile CT was used to scan the head continuously for CTPI imaging in areas of interest. The scanning conditions were with tube voltage 120 kV and tube current 8 mA. The scanning thickness was 1.1 mm and layer spacing was 4.1 mm in the trial. The brain blood flow (CBF), brain blood volume (CBV), contrast agent mean transit time (MTT) and peak to time (TTP) were calculated in the ischemic areas of interest and the corresponding healthy lateral brain by way of advanced imaging processing system of Anythink CT 16 and the algorithm of deconvolution methods. Results The results and imaging qualities of continuous dynamic scanning for CTPI with 16-slices mobile CT were in line with clinical diagnostic criteria. CTPI showed that there was no significant difference in CBF (25.226±6.458) mL·100 g^-1·min^-1, CBV (2.756±0.734) mL/100 g, MTT (3.365±1.450) s, TTP (22.314±4.884) s in the ischemic areas of interest, and compared with CBF(29.672±8.879)mL·100 g^-1·min^-1, CBV (3.714±0.401) mL/100 g, MTT (1.730±0.807) s, and TTP (22.424±5.395) s on the healthy side brain (P>0.05). Conclusion A new method of 16-slices mobile CT perfusion imaging had been established successfully. The CTPI imaging was high quality and the data was reliable in the stril.

关 键 词：脑卒中 移动CT 脑灌注成像 脑血流量 脑血容量 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R816.1[医药卫生—临床医学]