丹参多酚酸治疗急性脑梗死的临床疗效及对炎症因子的影响  

Effect of salvianolic acid on acute cerebral infarction on nerve function,inflammatory factor of patients with severe ischemic stroke

作　　者：闫斌[1] 刘素梅[1] 李卫君[1] 朱明振[1] 刘远洪[1] 聂志余[2] YAN Bin;LIU Sumei;LI Weijun;ZHU Mingzhen;LIU Yuanhong;Nie Zhiyu(Department of Neurology,People's Hospital of Puyang,Puyang 457000,China;Department of Neurology,Tongji Hospital,Medical School of Tongji University,Shanghai 200065,China)

机构地区：[1]濮阳市人民医院神经内科,河南濮阳457000 [2]同济大学医学院附属同济医院神经内科,上海200065

出　　处：《中国实用神经疾病杂志》2018年第23期2623-2627,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的观察注射用丹参多酚酸治疗急性脑梗死的临床疗效及对血清炎症因子的影响。方法选择176例急性脑梗死患者随机分为治疗组、对照组各88例。对照组按脑梗死常规方法治疗,治疗组在对照组的基础上加用注射用丹参多酚酸,均治疗2周,治疗前后评估美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)及日常生活能力评定量表(Barthel index,BI)评分,观察治疗前后血清炎症因子[C反应蛋白(creactive protein,CRP)、降钙素原(procallcitonin,PCT)及脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA_2)]水平浓度变化,并记录不良反应。结果治疗前2组NIHSS评分、BI评分、CRP、PCT、Lp-PLA_2比较,差异无统计学意义(P>0.05)。治疗后2组的NIHSS评分、CRP、PCT、LpPLA_2水平均显著降低,BI评分显著升高,且治疗组显著优于对照组,差异均有统计学意义(P<0.01)。治疗组总有效率明显优于对照组,差异有统计学意义(P<0.01),2组均未见明显不良反应。结论注射用丹参多酚酸治疗急性脑梗死安全有效,能有效改善神经功能缺损,减轻炎症反应。Objective To observe the clinical efficacy of salvia miltiorrhiza injection in the treatment of acute cerebral infarction and its effect on serum inflammatory factors.Methods A total of 176 patients with acute cerebral infarction were randomly divided into treatment group and control group.The control group was treated according to the conventional method of cerebral infarction.The treatment group was treated with the injection of salvianolic acid for more than 2 weeks.The National Institutes of Health Stroke Scale(National Institutes of Health Stroke Scale)and Barthel index(BI)scores were assessed before and after treatment.Serum inflammatory factors[C reactive protein(CRP),procallcitonin(PCT)and lipoprotein associated phospholipase A2,Lp-PLA2)]levels were observed and adverse reactions were recorded.Results There were no significant differences in NIHSS score,BI score,CRP,PCT and Lp-PLA2 between the two groups before treatment(P>0.05).After treatment,the NIHSS scores,CRP,PCT,and Lp-PLA2 levels in the two groups were significantly lower,and the BI scores were significantly higher,and the treatment group was significantly better than the control group,and the difference was statistically significant(P<0.01).The total effective rate of the treatment group was significantly better than that of the control group,and the difference was statistically significant(P<0.01).No obvious adverse reactions were observed in the two groups.Conclusion Danshen polyphenolic acid for injection is safe and effective in the treatment of acute cerebral infarction,which can effectively improve neurological deficit and reduce inflammation.

关 键 词：注射用丹参多酚酸 急性脑梗死 C反应蛋白 降钙素原 脂蛋白相关磷脂酶A2 

分 类 号：R743.33[医药卫生—神经病学与精神病学]