非酒精性脂肪性肝病进展性肝纤维化危险因素分析  

Analysis on risk factors of nonalcoholic fatty liver disease progressive hepatic fibrosis

作　　者：王燕[1] 马燕[2] 吴琦琦 庄小芳[2] 王晓波[2] 王晓忠[2] WANG Yan;MA Yan;WU Qiqi;ZHUANG Xiaofang;WANG Xiaobo;WANG Xiaozhong(Department of Traditional Chinese Medicine,Chengdu Fifth People’s Hospital,Chengdu 611130;Department of Hepatology,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,China)

机构地区：[1]成都市第五人民医院中医科,四川成都611130 [2]新疆医科大学附属中医医院肝病科

出　　处：《胃肠病学和肝病学杂志》2019年第1期96-100,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金项目(81560745)

摘　　要：目的分析非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者肝纤维化危险因素。方法选取新疆医科大学附属中医医院2016年6月至2017年6月就诊的NAFLD患者进行横断面分析,根据Fibro Touch所检测的肝弹性值将209例患者分为无或轻度肝纤维化组(n=112)及进展性肝纤维化组(n=97)。运用Spearman相关分析、Logistic回归分析可能发生肝纤维化的影响因素。结果两组患者在BMI、肝弹性值、CAP、ALT、AST、TG、Ins之间差异有统计学意义(P <0. 05)。各研究因素与肝纤维化相关性分析显示,脂肪肝肝纤维化与年龄、BMI、ALT、AST、TG、CAP、Ins呈正相关(P <0. 05)。非条件二分类变量Logistic回归分析显示,BMI、CAP、ALT、TG、Ins是NAFLD进展性肝纤维化的独立危险因素(P均<0. 05)。结论肥胖、血脂异常、胰岛素抵抗等代谢危险因素增加NAFLD患者肝纤维化的发生风险,与纤维化进展相关。Objective To investigate the risk factors of liver fibrosis in nonalcoholic fatty liver disease(NAFLD)patients.Methods A cross-sectional analysis was performed on NAFLD patients form Jun.2016 to Jun.2017 in the Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University.Aaccording to the liver elasticity measured by FibroTouch,209 patients were divided into no or mild hepatic fibrosis group(n=112)and progressive liver fibrosis group(n=97).Spearman correlation analysis and Logistic regression analysis were used to analyze the factors influencing liver fibrosis.Results There were significant differences in BMI,liver elasticity,CAP,ALT,AST,TG,Ins between two groups(P<0.05).Correlation analysis between each factor and hepatic fibrosis showed that fatty liver fibrosis was positively related with age,BMI,ALT,AST,TG,CAP and Ins(P<0.05).Logistic regression analysis showed that BMI,CAP,ALT,TG and Ins were independent risk factors of NAFLD progression of hepatic fibrosis(all P<0.05).Conclusion Metabolic risk factors such as obesity,dyslipidemia and insulin resistance increase the risk of hepatic fibrosis in patients with NAFLD and they are related to the progress of fibrosis.

关 键 词：NAFLD 肝纤维化 危险因素 

分 类 号：R575[医药卫生—消化系统]