清金化痰汤治疗非小细胞肺癌临床研究  

Clinical observation of non-small cell lung cancer patients treated with Qingjin Huatan decoction

作　　者：刘月芬[1] 刘小红[2] 于明军 姜祖光[1] 朱明艳 LIU Yuefen;LIU Xiaohong;YU Mingjun(Department of Oncology,Puyang Oilfield General Hospital,Puyang457001)

机构地区：[1]河南省濮阳市油田总医院肿瘤一科,濮阳457001 [2]新乡医学院第一附属医院药剂科,新乡4531000

出　　处：《陕西中医》2019年第2期229-232,共4页Shaanxi Journal of Traditional Chinese Medicine

摘　　要：目的 :探讨清金化痰汤治疗非小细胞肺癌患者的临床疗效。方法 :选取非小细胞肺癌患者106例,根据随机数表法分为观察组和对照组,各53例,对照组患者给予GP(吉西他滨+顺铂)方案化疗,观察组患者在此基础上给予清金化痰汤进行联合治疗,2个月为一疗程。比较两组治疗疗效,并对患者VEGF水平、免疫功能、肿瘤标志物指标水平进行比较,观察治疗过程中两组毒副反应发生情况。结果:经过治疗,观察组患者45例有效,有效率84.91%;对照组35例有效,有效率66.04%,两组疗效差异有统计学意义(P<0.05);治疗前,两组患者VEGF水平无明显差异(P>0.05);治疗后,两组VEGF-A、VEGF-B、VEGF-C水平均降低,且观察组降低程度较对照组明显,差异有统计学意义(P<0.05);治疗前,两组患者CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+无明显差异(P>0.05);治疗后,两组CD_3^+、CD_4^+、CD_4^+/CD_8^+均降低,CD_8^+均升高,且观察组升高降低程度较对照组明显,差异有统计学意义(P<0.05);治疗前,两组患者肿瘤标志物指标水平无明显差异(P>0.05);治疗后,两组CEA、CA125、CYFRA21-1水平均降低,且观察组降低程度较对照组明显,差异有统计学意义(P<0.05);观察组患者出现恶心呕吐、白细胞减少、肝功受损、血小板降低、便秘等不良反应例数少于对照组,差异有统计学意义(P<0.05)。结论 :清金化痰汤治疗非小细胞肺癌患者临床疗效显著,可改善患者免疫功能,有效抑制患者VEGF水平,减少化疗的毒副反应。Objective:Explore the clinical effect of Qingjin Huatan decoction in the treatment of non-small cell lung cancer patients.Methods:Selected 106 cases of patients with non-small cell lung cancer,according to the stochastic indicator method is divided into observation group and control group,53 cases,control group patients give GP(gemcitabine plus cisplatin)scheme chemotherapy,on the basis of the observation group patients give Qingjin Huatan decoction for combination therapy,2 months for a course of treatment.The efficacy of the two groups was compared,and the levels of VEGF,immune function and tumor markers were compared,and the two groups of adverse reactions were observed during the treatment.Results:After treatment,45 patients in the observation group were effective,with an effective rate of 84.91%.In the control group,35 cases were effective,and the effective rate was 66.04%,and the difference between the two groups was statistically significant(P﹤0.05).There was no significant difference in VEGF level between the two groups before treatment(P﹥0.05).After treatment,the levels of vegf-a,vegf-b and vegf-c were all decreased in both groups,and the decrease of the observation group was significantly lower than that in the control group,with statistically significant difference(P﹤0.05).Before treatment,there was no significant difference between CD3^+,CD4^+,CD8^+and CD4^+/CD8^+in the two groups(P﹥0.05).After treatment,both groups of CD3^+,CD4^+,CD4^+/CD8^+decreased,and the CD8+increased,and the decrease of the observation group was significantly lower than that in the control group,and the difference was statistically significant(P﹤0.05).Before treatment,there was no significant difference in markers of tumor markers in the two groups(P﹥0.05).After treatment,the levels of CEA,CA125 and cyfra21-1 were all decreased,and the decrease of the observation group was significantly lower than that in the control group,with statistically significant difference(P﹤0.05).The number of adverse reactions in the obse

关 键 词：清金化痰汤 非小细胞肺癌 临床疗效 VEGF水平 免疫功能 肿瘤标志物 

分 类 号：R743.2[医药卫生—神经病学与精神病学]