Repair of long segmental ulnar nerve defects in rats by several different kinds of nerve transposition  

作　　者：Fei Yu You-Lai Yu Su-Ping Niu Pei-Xun Zhang Xiao-Feng Yin Na Han Ya-Jun Zhang Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang 

机构地区：[1]Peking University People's Hospital [2]The Affiliated Hospital of Xuzhou Medical University

出　　处：《Neural Regeneration Research》2019年第4期692-698,共7页中国神经再生研究（英文版）

基　　金：funded by the National Natural Science Foundation of China,No.31571236,31571235(to YHK,PXZ);National Key Research and Development Program of China,No.2016YFC1101604(to DYZ);National Key Basic Research Program of China(973 Program),No.2014CB542200(to BGJ);Ministry of Education Innovation Program of China,No.IRT_16R01(to BGJ);Beijing Science and Technology New Star Cross Program of China,No.2018019(to PXZ)

摘　　要：Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve transposition repair, the regenerated nerve fibers of motor neurons in the anterior horn of the spinal cord can effectively grow into the repaired distal nerve and target muscle tissues, which is conducive to the recovery of motor function. The aim of this study was to explore regeneration and nerve functional recovery after repairing a long-segment peripheral nerve defect by transposition of different donor nerves. A long-segment(2 mm) ulnar nerve defect in Sprague-Dawley rats was repaired by transposition of the musculocutaneous nerve, medial pectoral nerve, muscular branches of the radial nerve and anterior interosseous nerve(pronator quadratus muscle branch). In situ repair of the ulnar nerve was considered as a control. Three months later, wrist flexion function, nerve regeneration and innervation muscle recovery in rats were assessed using neuroelectrophysiological testing, osmic acid staining and hematoxylin-eosin staining, respectively. Our findings indicate that repair of a long-segment ulnar nerve defect with different donor nerve transpositions can reinnervate axonal function of motor neurons in the anterior horn of spinal cord and restore the function of affected limbs to a certain extent.Multiple regeneration of axonal buds has been shown to exist during the repair of peripheral nerve injury, which confirms a certain repair potential of the injured peripheral nerve. Therefore, a systematic nerve transposition repair technique has been proposed to treat severe peripheral nerve injury. During nerve transposition repair, the regenerated nerve fibers of motor neurons in the anterior horn of the spinal cord can effectively grow into the repaired distal nerve and target muscle tissues, which is conducive to the recovery of motor function. The aim of this study was to explore regeneration and nerve functional recovery after repairing a long-segment peripheral nerve defect by transposition of different donor nerves. A long-segment(2 mm) ulnar nerve defect in Sprague-Dawley rats was repaired by transposition of the musculocutaneous nerve, medial pectoral nerve, muscular branches of the radial nerve and anterior interosseous nerve(pronator quadratus muscle branch). In situ repair of the ulnar nerve was considered as a control. Three months later, wrist flexion function, nerve regeneration and innervation muscle recovery in rats were assessed using neuroelectrophysiological testing, osmic acid staining and hematoxylin-eosin staining, respectively. Our findings indicate that repair of a long-segment ulnar nerve defect with different donor nerve transpositions can reinnervate axonal function of motor neurons in the anterior horn of spinal cord and restore the function of affected limbs to a certain extent.

关 键 词：NERVE REGENERATION NERVE TRANSPOSITION REPAIR conical SLEEVE small gap SLEEVE bridging ULNAR NERVE target organ muscle NERVE reinnervation neural REGENERATION 

分 类 号：R459.9[医药卫生—治疗学] R361[医药卫生—临床医学]