特发性黄斑裂孔患者视网膜敏感度与视觉相关生活质量的关系  

Relationship of mean retinal sensitivity with vision-related quality of life in patients with idiopathic macular hole

作　　者：王曾仪 梁曦达 郁艳萍 王敬 刘武 Wang Zengyi;Liang Xida;Yu Yanping;Wang Jing;Liu Wu(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,眼科学与视觉科学北京市重点实验室,北京100730

出　　处：《中华实验眼科杂志》2019年第1期35-39,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家重点研发计划项目(2017YFA0104103).

摘　　要：目的探讨特发性黄斑裂孔(IMH)患者患眼及健眼视网膜敏感度(MS)与视觉相关生活质量的关系。方法采用前瞻性队列研究设计,纳入2017年5—9月于北京同仁医院眼科门诊就诊的单眼IMH患者31例31眼,采用美国国家眼科学会视功能问卷(NEI VFQ-25)中文版评估患者视觉相关生活质量(VR-QoL)。采用MP-3微视野计检测患者的患眼及健眼黄斑区视网膜敏感度。比较患眼与健眼间MS和BCVA的差异,评估BCVA、年龄、MS、黄斑裂孔最小直径与视觉相关生活质量评分的关系。结果视觉相关生活质量问卷总分(患眼:ρ=0.484,P=0.006;健眼:ρ=0.387,P=0.031)及近距离(患眼:ρ=-0.353,P=0.048;健眼:ρ=0.352,P=0.048)、远距离(患眼:ρ=0.496,P=0.004;健眼:ρ=0.415,P=0.015)亚项与双眼分别的视网膜敏感度相关,而与最佳矫正视力(BCVA)、裂孔直径无明显相关性(均P>0.05);患眼视网膜敏感度与问卷总分相关性最强。结论视网膜敏感度可以更全面地反映IMH患者视网膜功能。单眼IMH患者的视觉相关生活质量与其双眼视网膜敏感度有关,但IMH主要受患眼的影响。黄斑裂孔疾病可能影响患者的近距离和远距离活动。Objective To evaluate the relationship of retinal sensitivity (MS) with vision-related quality of life in patients with idiopathic macular hole (IMH).Methods A prospective cohort study was performed in this study.Thirty-one monocular IMH patients were enrolled in Beijing Tongren Hospital from May to September of 2017.Vision-related quality of life (VR-QoL) was analyzed in 31 patients with National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25)(Chinese version),and MS in the affected eye and the fellow eye in these patients was detected by Microperimeter-3.MS and best corrected visual acuity (BCVA) between the affected eye and the fellow eye were compared.The correlations among BCVA,age,MS,minimum macular hole diameter,composite scores and subscales score were evatuateds.This study protocol was approved by Ethic Committee of Beijing Tongren Hospital.This study complied with Declaration of Helsinki.Results There were significant correlations between composite scores and MS in the affected eye and the fellow eye (affected eye:ρ=0.484,P=0.006;fellow eye:ρ=0.387,P=0.031).Significante correlations were shown in near activities (affected eye:ρ=-0.353,P=0.048;fellow eye:ρ=0.352,P=0.048) and distance activities (affected eye:ρ=0.496,P=0.004;fellow eye:ρ=0.415,P=0.015).No obvious correlations were shown between VR-QoL and BCVA or minimum hole diameter.The correlation between composite scores and the MS in the affected eye was the most strong.Conclusions MS can reflect the retinal function in patients of IMH more widely.The correlations VR-QoL and MS is correlated in the affected eye and fellow eye in patients of monocular IMH,however,patient's VR-QoL dependes more on the affected eye.IMH can violate the patient's near and distance activities.

关 键 词：黄斑裂孔 特发性 视网膜敏感度 生活质量 视觉相关 

分 类 号：R774.5[医药卫生—眼科]