息肉样脉络膜血管病变诊疗进展  

Current advance of polypoidal choroidal vasculopathy in diagnosis and treatment

作　　者：周楠(综述) 魏文斌(审校) Zhou Nan;Wei Wenbin(Beijing Tongren Eye Center,Beijing Ophthalmology Visual Sciences Key Lab,Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科学与视觉科学重点实验室,眼内肿瘤诊治研究北京市重点实验室,100730

出　　处：《中华实验眼科杂志》2019年第1期77-80,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目(81570891、81272981);北京市自然科学基金项目(7151003);北京市卫生系统高层次卫生技术人才培养计划项目(2014-2-003);北京市医院管理局“登峰”人才培养计划项目(DFL20150201);北京市医院管理局临床医学发展专项经费资助(扬帆计划)项目(ZYLX201307);恶性葡萄膜黑色素瘤综合诊断及治疗策略的研究项目(首发2016-1-2051);眼内肿瘤诊治研究北京市重点实验室2015年度科技创新基地培育与发展专项项目(Z151100001615052).

摘　　要：息肉样脉络膜血管病变(PCV)是以脉络膜异常分支状血管网及末端息肉样血管扩张病灶为特点的血管性病变。PCV是一个独立的疾病还是湿性年龄相关性黄斑变性(AMD)的一个亚型,目前尚有争议。光相干断层扫描血流成像(OCTA)作为一种新的眼科影像检查技术,具备无创、快速、分辨率高的特点,其对血流的显影不受血管渗漏和视网膜出血的影响,能够提供三维测量的病变图像,并能实现病变的定量检测和分层检测和分析。OCTA用于多种眼科疾病的诊断和病情监测,有助于对PCV这类血管性疾病的认识。PCV的治疗经历了不同的阶段,目前已经进入抗血管内皮生长因子(VEGF)的时代,绝大多数PCV通过单纯抗VEGF治疗能够取得较好的疗效。本文就PCV的临床特征、诊断和治疗进展进行综述。Polypoidal choroidal vasculopathy (PCV) is a kind of fundus disease characterized by choroidal anomalous branch vascular network and terminal polypoidal dilatation.The pathological basis of idiopathic choroidal neovascularization is similar to age-related macular degeneration (AMD).It is controversial that whether PCV and AMD is the same disease.Optical coherence tomography angiography (OCTA) is a new,noninvasive imaging technique that plays an important role in clinical practice.OCTA not only provides B-scans of the retina,but also offers rapid,high-resolution,repeated and accurate visualization of blood flow,which provides representation of the vascular morphology of the retina and choroid.OCTA is a noninvasive imaging modality capable of evaluating and assessing the morphology of PCV and their associated vascular patterns.The vascular endothelial growth factor (VEGF) participates in the pathophysiology of PCV,so anti-VEGF therapy has become the first-line treatment for PCV.Intravitreal injection of bevacizumab,ranibizumab,and aflibercept improves and stabilizes the vision of patients with PCV.In this article,we summarized the new progress of diagnosis and treatment associated with PCV.

关 键 词：息肉样脉络膜血管病变 光相中断层扫描血流成像 临床特征 诊断 治疗 

分 类 号：R773.4[医药卫生—眼科]