中西医结合治疗在脾胃虚寒型慢性萎缩性胃炎患者中的应用效果观察  

Therapeutic effect of combined traditional Chinese and Western medicine treatment in patients with chronic atrophic gastritis of spleen-stomach deficiency-cold type

作　　者：朱微微 姚憬 池美华 王忠建 Wei-Wei Zhu;Jing Yao;Mei-Hua Chi;Zhong-Jian Wang(Department of Internal Traditional Chinese Medicine,Wenzhou Integrated Hospital of Traditional Chinese and Western Medicine,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]温州市中西医结合医院中医内科,浙江省温州市325000

出　　处：《世界华人消化杂志》2018年第36期2120-2126,共7页World Chinese Journal of Digestology

摘　　要：目的研究参芪健胃颗粒联合替普瑞酮对脾胃虚寒型慢性萎缩性胃炎患者胃肠激素和炎症因子的影响.方法选取2016-09/2017-09于温州市中西医结合医院治疗的脾胃虚寒型慢性萎缩性胃炎的患者150例,按照随机数字表法,将其分为试验组和对照组各75例,两组均予以阿莫西林抗感染、奥美拉唑与胶体果胶铋抑酸保护胃黏膜治疗,对照组在常规治疗基础上予以替普瑞酮口服治疗,试验组在对照组基础上予以参芪健胃颗粒口服治疗.连续治疗4 mo后,分析比较两组患者在临床疗效、中医证候评分、血清胃肠激素、炎症因子水平和幽门螺杆菌(Helicobacter pylori,H. pylori)治疗有效率.结果试验组总有效率高于对照组,差异有统计学意义(P <0.05);治疗后,两组患者上腹饱胀、胃部刺痛、纳差食少和倦怠乏力证候评分均较同组治疗前显著降低(P <0.05);且治疗后试验组中医证候评分显著低于对照组(P <0.05);治疗前,两组患者血清中胃肠激素内皮素(endothelin, ET)、表皮生长因子(epidermal growth factor,EGF)、降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、白细胞介素-8(Interleukin-8,IL-8)、白细胞介素-6(Interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)水平无明显差异(P>0.05),治疗后两组患者ET、EGF、IL-8、IL-6、TNF-α低于治疗前, CGRP高于治疗前,且试验组各指标改善程度优于对照组,差异有统计学意义(P<0.05);试验组治疗后H. pylori治疗有效率高于对照组,差异有统计学意义.结论参芪健胃颗粒联合替普瑞酮治疗脾胃虚寒型慢性萎缩性胃炎临床疗效显著,有效改善患者临床症状缓解病情,值得临床上推广应用.AIM To assess the influence of Shenqi Jianwei granules combined with teprenone on gut hormones and inflammatory factors in patients with chronic atrophic gastritis of spleen-stomach deficiency-cold type.METHODS A total of 150 patients with chronic atrophic gastritis of spleen-stomach deficiency-cold type who were treated at Wenzhou Integrated Hospital of Traditional Chinese and Western Medicine from September 2016 to September 2017 were randomly divided into an experimental group and a control group,with 75 cases in each group.Both groups were treated with amoxicillin for anti-infection as well as omeprazole and colloidal pectin to protect the gastric mucosa by acid suppression.Both groups were treated with oral teprenone on the basis of routine treatments,and the experimental group was additionally treated with Shenqi Jianwei granules.After four months of treatment,the clinical efficacy,TCM syndromes scores,serum levels of gut hormones and inflammatory factors,and treatment efficacy for Helicobacter pylori(H.pylori)infection were compared between the two groups.RESULTS The clinical efficacy was better in the experimental group than in the control group(P<0.05).After treatment,the TCM syndrome scores of abdominal distension,stomach pain,anorexia,and fatigue in both groups were significantly decreased compared with the scores before treatment(P<0.05),and these TCM syndrome scores in the experimental group were significantly lower than those in the control group(P<0.05).Before treatment,there was no significant difference in the levels of endothelin(ET),epidermal growth factor(EGF),calcitonin gene-related peptide(CGRP),interleukin-6(IL-6),interleukin-8(IL-8),or tumor necrosis factoralpha(TNF-α)between the two groups(P>0.05).After treatment,the levels of ET,EGF,IL-8,IL-6,and TNF-α were decreased and the CGRP was increased in both groups compared with those before treatment,and the improvement of each index in the experimental group was significantly better than that in the control group(P<0.05).The treatment effic

关 键 词：参芪健胃颗粒 替普瑞酮 慢性萎缩性胃炎 炎症因子 胃肠激素 

分 类 号：R573.32[医药卫生—消化系统]