DNA甲基化在胰腺癌早期诊断及治疗中的研究进展  

Application of DNA methylation in early diagnosis and treatment of pancreatic cancer

作　　者：卢家俊 袁周[1] Jia-Jun Lu;Zhou Yuan(Department of General Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院普外科,上海市200233

出　　处：《世界华人消化杂志》2019年第1期13-19,共7页World Chinese Journal of Digestology

摘　　要：胰腺癌(pancreatic cancer, PC)是恶性程度最高的消化道系统肿瘤之一,多数患者就诊时已属中晚期从而失去根治性手术机会,导致5年生存率不到5%. PC患者外周血中循环肿瘤DNA浓度明显高于正常健康人群,并且携带有肿瘤特有的基因突变与甲基化改变.DNA甲基化是表观遗传学的重要表现形式,也是肿瘤发生中的早期事件,早于基因突变并且可以出现在PC进展的各个阶段.因此, PC患者启动子区异常DNA甲基化的检测可能为肿瘤的早期诊断、预后评价以及复发监测提供了一种简便的、无创的有效方法.本文就近年来人们对于DNA甲基化在PC早期诊断中的研究进展及其对于PC治疗的潜在价值进行综述.Pancreatic cancer(PC)is one of the most malignant gastrointestinal tumors,characterized by a poor prognosis.Most of the patients have an advanced disease at the time of diagnosis and lose the opportunity of radical surgery,resulting in a 5-year survival rate of less than 5%.Circulating tumor DNA,whose concentration in plasma of patients with pancreatic adenocarcinoma is higher than that in health controls,carries specific gene mutation and aberrant DNA methylation.Epigenetic change is one of the important characteristics of cell carcinogenesis.DNA methylation is an early event in tumorigenesis,which is more helpful for early diagnosis than gene mutation and can be observed in each stage of PC.Therefore,the detection of aberrant DNA methylation in the promoter region in patients with PC may be a non-invasive method for early cancer detection,predicting prognosis,and monitoring recurrence.In the present review,we discuss the recent advances in the study of DNA methylation in the early diagnosis of PC,and the potential application value in the treatment of PC.

关 键 词：DNA甲基化 CTDNA 胰腺癌 早期诊断 治疗 

分 类 号：R735.9[医药卫生—肿瘤]