抑癌基因甲基化与骨肉瘤的关系  

Relationship between tumor suppressor gene methylation and osteosarcoma

作　　者：覃娜 王艳华[1] QIN Na;WANG Yan-hua(Medical College of China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,湖北宜昌443002

出　　处：《基础医学与临床》2019年第2期256-259,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81602559)

摘　　要：骨肉瘤的发生机制与多种抑癌基因失活甚至缺失有关,其中包括PTEN、WWOX、WIF-1、SPARCL1和p53等,而这些基因均对骨肉瘤的生长具有抑制作用。甲基化是重要的表观遗传学特征之一,以‘抑癌基因甲基化’为骨架节点的相关研究为骨肉瘤的临床诊断、治疗及其发病机制的阐释提供了重要支撑,也为新型抗骨肉瘤药物的研发提供了巧妙思路。The pathogenesis mechanism of osteosarcoma is closely related to the expression inactivation or even loss of multiple tumor suppressor genes,including PTEN,WWOX,WIF-1,SPARCL1,p53,which inhibite the growth of osteosarcoma.Methylation is one of the important epigenetic features,and the research on the methylation of these tumor suppressor genes provided valuable or fundamental support to clinical diagnosis,treatment and pathogenesis identification of osteosarcoma,which also offers an ingenious orientation to develop new anti-osteosarcoma drugs.

关 键 词：抑癌基因 甲基化 骨肉瘤 治疗 

分 类 号：R738[医药卫生—肿瘤]