Livin蛋白和STAT3蛋白在支气管肺癌中的表达及临床意义  

Expression and clinical significance of Livin protein and STAT3 protein in bronchogenic carcinoma

作　　者：柴春艳 刘娅萍[1] 王甜[1] 杜洁[2] 李雅莉[3] 徐邦强[1] 赵媛[1] Chai Chunyan;Liu Yaping;Wang Tian;Du Jie;Li Yali;Xu Bangqiang;Zhao Yuan(1st Impatient Area of West Court,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;The Health Examination Centre,Shaanxi Provincial People's Hospital,Shaanxi Xi'an 710068,China;Department of Respiratory Medicine,the Second Affiliated Hospital,Medical School of Xi'an Jiaotong University,Shaanxi Xi'an 710004,China)

机构地区：[1]陕西省人民医院西院一病区,陕西西安710068 [2]陕西省人民医院健康体检中心,陕西西安710068 [3]西安交通大学第二附属医院呼吸内科,陕西西安710004

出　　处：《现代肿瘤医学》2019年第3期420-424,共5页Journal of Modern Oncology

摘　　要：目的:探讨Livin蛋白和STAT3蛋白在支气管肺癌组织中的表达,及蛋白表达与临床病理特征的关系。方法:采用免疫组化二步法(SP法)检测在支气管肺癌组织及癌旁病理证实的正常肺组织和肺部良性病变组织中Livin蛋白和STAT3蛋白的表达情况。结果:肺癌组的Livin蛋白和STAT3蛋白阳性表达率均高于对照组(均为P <0. 05)。男性肺癌患者肺组织、有淋巴结转移肺组织、吸烟指数≥400年支的肺癌患者肺组织中Livin蛋白和STAT3蛋白的阳性表达率均较高,差异有统计学意义(P <0. 05)。肺腺癌组织Livin蛋白的阳性表达率显著高于肺鳞癌组织,差异有统计学意义(P=0. 009)。低分化肺癌组织中STAT3蛋白阳性表达率明显高于中分化肺癌组织,差异有统计学意义(P=0. 004)。支气管肺癌患者的年龄、临床分期对Livin蛋白和STAT3蛋白的阳性表达率的影响均无统计学差异(P> 0. 05)。Livin蛋白与STAT3蛋白的表达呈正相关。结论:Livin蛋白与STAT3蛋白在支气管肺癌组织中过表达,有望为肿瘤诊断及基因治疗提供新的靶点。Livin蛋白与STAT3蛋白在支气管肺癌组织中表达呈正相关。Objective:To investigate the expression of Livin protein and STAT3 protein in the tissues of lung cancer and their relationship with clinicopathological features.Methods:The protein expression of Livin and STAT3 gene in paraffin specimens of lung cancer and specimens of normal lung tissues were detected by SP immunohistochemistry.Results:The positive expression rate of Livin protein and STAT3 protein in lung cancer group were higher than that in the control group(P<0.05).The positive expression rates of Livin protein and STAT3 protein in lung tissue of male lung cancer patients,lymph node metastasis lung tissue,and lung cancer patients with smoking index≥400 were higher,and the differences were statistically significant(P<0.05).The expression of Livin protein in lung adenocarcinoma tissues was significantly higher than that in lung squamous cell carcinoma tissues.The differences were significant(P=0.009).The positive rate of STAT3 protein in poorly differentiated lung cancer was significantly higher than that in moderate differentiated lung cancer,and the difference was statistically significant(P=0.004).Livin protein and STAT3 protein in lung cancer had no obvious relationship with age and clinical stage(P >0.05).Livin protein expression was positively related to STAT3 protein expression in primary lung cancer.Conclusion:The overexpression of Livin protein and STAT3 protein in lung cancer tissue is expected to provide a new target for the diagnosis and gene therapy of tumor.The aberrant expression of Livin and STAT3 may play synergetic roles in process of carcinogenesis of lung cancer.

关 键 词：支气管肺癌 LIVIN蛋白 STAT3蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]