肿瘤嗜神经侵袭机制的研究进展  

Advances in the research of mechanism of perineural invasion in tumor

作　　者：黄婷 孙笑[1] 王玉东[1] Huang Ting;Sun Xiao;Wang Yudong(Department of Gynecology,International Peace Maternal and Child Health Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院妇科,上海200030

出　　处：《现代肿瘤医学》2019年第3期509-511,共3页Journal of Modern Oncology

基　　金：国家自然科学基金青年项目(编号:81402135);上海交通大学"医工交叉研究基金"面上项目(编号:YG2017MS41)

摘　　要：肿瘤嗜神经侵袭(perineural invasion,PNI)被认为是一种新的恶性肿瘤转移方式,与多种肿瘤不良预后相关。神经与肿瘤细胞之间的相互作用主要包括细胞形态的改变和分子间作用。肿瘤微环境中的多种分子包括神经营养因子、趋化因子、黏附分子及神经递质等在肿瘤PNI形成过程中发挥重要作用。探究神经与肿瘤的相互作用,可为揭示肿瘤形成或转移的机制及优化临床诊疗提供帮助。Perineural invasion(PNI)is considered to be a new type of the metastatic pathways of manligant tumors and is related to the prognosis of multiple tumors.The interactions between nerves and tumor cells mainly include changes in cell morphology and intermolecular interactions.A variety of molecules in the tumor microenvironment,including neurotrophic factors,chemokines,adhesion molecules and neurotransmitters,play an important role in the formation of tumor PNI.By understanding the interaction between nerves and tumors,it helps reveal the mechanism of tumor formation or metastasis as well as optimize clinical diagnosis and treatment.

关 键 词：神经 肿瘤 侵袭 

分 类 号：R730.231[医药卫生—肿瘤]