CENP-A与恶性肿瘤的相关性研究进展  

Research Progress of Correlation between CENP-A and Malignant Tumors

作　　者：丁文祎 黄丹 何珏[2,3] DING Wen-yi;HUANG Dan;HE Jue(Gannan Medical University,Postgraduate Student of Grade 2016,Ganzhou,Jiangxi 341000;Gannan Medical University,Postgraduate Student of Grade 2017,Ganzhou,Jiangxi 341000;Gannan Medical University,Dept.Of Pathology,Ganzhou,Jiangxi 341000;Gannan Medical University,Dept.Of Pathology of the First Affiliated Hospital,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院,江西赣州341000 [2]赣南医学院病理学教研室,江西赣州341000 [3]赣南医学院第一附属医院病理科,江西赣州341000

出　　处：《赣南医学院学报》2018年第12期1273-1278,共6页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：赣南医学院研究生创新课题(编号:YC2017-X004)

摘　　要：CENP-A作为最早被发现的一种着丝粒蛋白,它对于着丝粒的组装形成、染色体的正确分离以及细胞分裂的正常进行起到了不可替代的作用。近年来研究发现CENP-A在多种恶性肿瘤中过表达,这种过表达会导致染色体非整倍体的形成,而染色体非整倍体是肿瘤形成的重要原因之一。研究CENP-A的过表达与肿瘤的关系,对于肿瘤的靶向治疗具有重要的现实意义。CENP-A,as one of the earliest discovered centromere proteins,plays an irreplaceable role in the assembly of centromere,proper separation of chromosomes,and normal division of cells.In recent years,it has been found that CENP-A is overexpressed in a variety of malignant tumors.This overexpression leads to the formation of chromosome aneuploidy,which is one of the important causes of tumor formation.The study of the relationship between CENP-A overexpression and tumors has important practical significance for the targeted treatment of tumors.

关 键 词：CENP-A HJURP 恶性肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]