大蒜提取物S-烯丙基-L-半胱氨酸对小鼠放疗损伤保护作用的研究  

Protective effects of S-allyl-L-cysteine on radiotherapy injuries in mice

作　　者：尚志梅[1] 张丰春 赵斌[3] 杜忠海 Shang Zhimei;Zhang Fengchun;Zhao Bin;Du Zhonghai(Cancer Center;Emergency Department,Shouguang Hospital of Traditional Chinese Medicine,Shandong Shouguang 262700,China;Clinical Pharmacy Department,Weifang Traditional Chinese Medicine Hospital,Shandong Weifang 261041, China)

机构地区：[1]潍坊市中医院肿瘤中心,山东潍坊261041 [2]寿光市中医医院急诊科,山东寿光262700 [3]潍坊市中医院临床药学科,山东潍坊261041

出　　处：《现代肿瘤医学》2019年第4期561-564,共4页Journal of Modern Oncology

基　　金：潍坊市科技发展计划项目(编号:2014WS062)

摘　　要：目的:研究大蒜提取物S-烯丙基-L-半胱氨酸(S-allyl-L-cysteine,SAC)对小鼠放射治疗所致损伤的保护作用。方法:采用小鼠30 d存活率实验及对造血系统、免疫系统影响实验,即小鼠受7. 5 Gy剂量全身照射后,观察其存活情况及测外周血白细胞数、股骨有核细胞数、骨髓DNA含量、胸腺和脾指数的变化情况。结果:不同剂量的给药照射组小鼠30 d存活率比单纯照射组均有提高,对造血系统、免疫系统均有保护作用,特别是中剂量组存活率提高了50%,白细胞数、股骨有核细胞数、骨髓DNA含量和脾结节数分别从0. 17±0. 05、0. 56±0. 07、0. 21±0. 14和1. 02±0. 30提高到0. 67±0. 08、4. 45±1. 76、0. 58±0. 12和2. 71±0. 21,数据均有统计学意义(P <0. 05),并且SAC对胸腺、脾也有一定的保护作用。结论:大蒜提取物S-烯丙基-L-半胱氨酸对放射治疗所致损伤具有一定的保护作用。Objective: To investigate the radioprotective effect of S-allyl-L-cysteine (SAC) in garlic extract. Methods: 30 d survival experiment was used to observe the survival condition of mice 30 d after irradiation with 7.5 Gy γ-rays.Blood and immunological experiments of mice were carried out to observe white blood cell (WBC),femoral nucleated cells,bone marrow DNA content and organs index after irradiation with 7.5 Gy γ-rays. Results: The results showed that compared with the irradiation group,the survival rate of mice treated with SAC increased,especially for the middle dose group.Compared with the irradiation group,white blood cell count,the number of femoral nucleated cells in bone marrow,bone marrow DNA content and spleen nodules of mice administered with middle dose group increased from 0.17±0.05,0.56±0.07,0.21±0.14 and 1.02±0.30 to 0.67±0.08,4.45±1.76,0.58±0.12 and 2.71±0.21 respectively,which were statistically significant ( P <0.05).Moreover,SAC also had some protective effect on the organ. Conclusion: S-allyl-L-cysteine of garlic extract can reduce the radiotherapy injuries in mice.

关 键 词：S-烯丙基-L-半胱氨酸 放疗损伤 存活率 血液学指标 免疫学指标 

分 类 号：R730.53[医药卫生—肿瘤]