TACE联合中药治疗原发性肝癌伴门静脉癌栓的临床疗效观察  

Therapeutic effect of transcatheter arterial chemoembolization plus traditional chinese medicine on patients with primary hepatocellular carcinoma accompanied portal vein tumor thrombus

作　　者：覃岭[1] 赵微[1] 何峰[1] 吴维宇[1] QIN Ling;ZHAO Wei;HE Feng;Wu Weiyu(Digestive Department, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院消化内科,四川成都610500

出　　处：《西部医学》2019年第1期105-108,共4页Medical Journal of West China

摘　　要：目的观察经导管动脉化疗栓塞(TACE)联合中药对原发性肝癌伴门静脉癌栓患者的临床疗效观察。方法将58例原发性肝癌伴门静脉癌栓的患者,随机分为治疗组和对照组。对照组28例采用TACE介入联合常规治疗,治疗组30例在采取TACE介入的基础上辨证施治给予桃红四物汤+茵陈五苓散治疗,并于治疗前、后4周分别观察患者术后肝功能、AFP变化,中医证候疗效比较,增强CT检查评价治疗后肿瘤大小的变化。结果治疗后治疗组肝功能损害明显改善,AFP值较对照组显著降低(P<0.05),增强CT检查后观察肿瘤大小较对照组显著降低(P<0.05)。治疗组中医证候疗效比对照组明显提高。结论 TACE联合桃红四物汤+茵陈五苓散治疗原发性肝癌伴门静脉癌栓较单纯TACE介入治疗可明显降低术后肝功能的损害,缩小肿瘤大小,提高肝癌晚期伴门静脉癌栓的中医证候疗效和患者生存质量。Objective To investigate the effect of intervention of transcatheter arterial chemoembolization (TACE) plus Chinese herb on patients with primary Hepatocellular Carcinoma accompanied portal vein tumor thrombus. Methods 58 primary hepatocellular carcinoma with portal vein tumor thrombus were randomly divided into two groups. 30 Patients were treated with TACE plus traditional Chinese medicine (TCM). 28 Patients were treated with TACE only. Liver function, AFP, TCM symptoms curative effect and tumor size were studied and compared between the two groups. Result The levels of liver function, AFP and tumor sizes were decreased more significantly in the treatment group than those in the control group. The levels of TCM symptoms were increased more significantly than that in the treatment group. Conclusions TACE plus traditional Chinese medicine can improved liver function and TCM symptoms curative effect and tumor size in patients with Primary Hepatocellular Carcinoma accompanied portal vein tumor thrombus.

关 键 词：原发性肝癌 门静脉癌栓 TACE 桃红四物汤 茵陈五苓散 

分 类 号：R735.7[医药卫生—肿瘤]