肝脏微环境中各种细胞对肝星状细胞活化的影响  

Effect of various cells on the activation of hepatic stellate cells in liver microenvironment

作　　者：徐莹[1] 张定棋 陈佳美[1] 刘伟[1] 刘平[1,2] XU Ying;ZHANG Dingqi;CHEN Jiamei(Key Laboratory of Liver and Kidney Diseases(Ministry of Education)&Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Institute of Liver Diseases,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室上海市中医临床重点实验室,上海201203 [2]上海中医药大学上海高校中医内科学E-研究院,上海201203

出　　处：《临床肝胆病杂志》2019年第2期424-430,共7页Journal of Clinical Hepatology

基　　金：国家自然科学基金重点项目(81530101);国家自然科学基金项目(81703681);上海市青年科技英才扬帆计划资助项目(17YF1419800);中国博士后科学基金资助项目(2016M601643)

摘　　要：肝纤维化是以肝脏细胞外基质过度沉积或疤痕组织过度增生为特点的动态病理过程。肝星状细胞(HSC)的活化被普遍认为是形成肝纤维化的中心环节。HSC的活化受到肝脏微环境中各种复杂因素的调控,包括理化刺激和细胞间交互作用等。肝脏内固有细胞及免疫细胞与HSC共同构建了一个复杂的调控系统,调控HSC的活化过程及其转归。主要介绍了肝脏微环境中各种细胞对HSC活化的调控作用,旨在为新型的抗纤维化诊疗手段的研究拓展思路。Liver fibrosis is a dynamic pathological process characterized by excessive deposition of extracellular matrix(ECM)or hyperplasia of scar tissue.The activation of hepatic stellate cells(HSCs)is generally considered the central link in the formation of liver fibrosis.HSC activation is regulated by various factors in liver microenvironment,including physical and chemical stimulations and intercellular interactions.Intrinsic cells and immune cells in the liver and HSCs together establish a complex regulatory system to regulate HSC activation and regression.This article introduces the regulatory effect of the cells in liver microenvironment on HSC activation,in order to expand thinking for the research on new diagnosis and treatment methods for liver fibrosis.

关 键 词：肝硬化 脂细胞 细胞因子类 综述 

分 类 号：R575.2[医药卫生—消化系统]