小儿黄龙颗粒联合盐酸托莫西汀治疗注意缺陷多动障碍的临床疗效观察  

Clinical therapeutic effects on attention deficit hyperactivity disorder treated with xiaoer huanglong granules and atomoxetine hydrochloride

作　　者：杨萌[1] 孙继超 韩新民[1,3] 尹东奇[1] YANG Meng;SUN Ji-chao;HAN Xin-min;YIN dong-qi(Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210023;First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning Guangxi 5300233;Jiangsu Chinese Medicine Hospital,Nanjing Jiangsu 210029)

机构地区：[1]南京中医药大学,江苏南京210023 [2]广西中医药大学第一附属医院,广西南宁5300233 [3]江苏省中医院,江苏南京210029

出　　处：《世界中西医结合杂志》2019年第1期82-85,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省高等学校自然科学研究面上项目(17KJB360004)

摘　　要：目的观察小儿黄龙颗粒联合盐酸托莫西汀治疗注意缺陷多动障碍(ADHD)的临床疗效。方法选取2015年10月至2016年9月期间诊断为ADHD,中医证属肝肾阴虚证的72例患儿,按照随机数字表法分为对照组和治疗组各36例。对照组单纯使用盐酸托莫西汀进行治疗,治疗组采用小儿黄龙颗粒和盐酸托莫西汀联合治疗。观察两组患儿治疗后临床疗效及Conners评分、SNAP-4量表评分情况。结果治疗8周后,对照组总有效率为69. 44%,治疗组为75. 00%,两组比较差异无统计学意义(P> 0. 05)。两组患儿Conners评分比较,治疗4周后,治疗组在冲动-多动及多动指数的评分与对照组有明显差异(P <0. 05);治疗8周后,治疗组在心身障碍及多动指数的评分与对照组比较差异有统计学意义(P <0. 05)。治疗4周后,治疗组SNAP-4评分与对照组存在显著差异(P <0. 05),而治疗8周后两组间比较差异无统计学意义(P> 0. 05)。结论小儿黄龙颗粒联合盐酸托莫西汀治疗ADHD证属肝肾阴虚者,能缩短起效时间,提高疗效,值得临床推广。Objective To observe the clinical therapeutic effects on attention deficit hyperactivity disorder(ADHD)treated with the combined medication with xiaoer huanglong granules and atomoxetine hydrochloride.Methods A total of 72 children diagnosed as ADHD of liver and kidney yin deficiency syndrome in TCM were collected from October 2015 to September 2016.According to the random number table,they were divided into a control group and a treatment group,36 cases in each one.In the control group,atomoxetine hydrochloride was simply used.In the treatment group,xiaoer huanglong granules were combined with atomoxetine hydrochloride.The clinical therapeutic effects,Conners score and SNAP-4 score were observed after treatment in the two groups.Results After 8-week treatment,the total effective rate was 69.44% in the control group and was 75.00% in the treatment group,without significant difference in comparison(P >0.05).Regarding the comparison of Conners scores in ADHD children between the two groups,after 4-week treatment,the index score of the compulsive behaviors-hyperactivity and hyperactivity in the treatment group was different obviously as compared with the control group(P<0.05).After 8-week treatment,the index score of the psychosomatic disorder and hyperactivity in the treatment group was different significantly as compared with the control group(P<0.05).After 4-week treatment,SNAP-4 score in the treatment group was different significantly as compared with the control group(P<0.05)and after 8-week treatment,the difference was not significant between the two groups(P >0.05).Conclusion The combined medication with xiaoer huanglong granules and atomoxetine hydrochloride shortens the onset time and improves the therapeutic effects on ADHD differentiated as liver and kidney yin deficiency in TCM.This therapy deserves to be promoted in clinical practice.

关 键 词：注意缺陷多动障碍 肝肾阴虚证 托莫西汀 小儿黄龙颗粒 

分 类 号：R749.94[医药卫生—神经病学与精神病学]