乳腺癌致病基因BRCA1的生物信息学分析  

Bioinformatics Analysis of Pathogenic gene BRCA1 in Breast Cancer

作　　者：辛艾玲 Xin Ailing(Experimental School of Chengdu No.7 Middle School,Sichuan,610000)

机构地区：[1]成都七中实验学校,四川610000

出　　处：《当代化工研究》2019年第1期186-188,共3页Modern Chemical Research

摘　　要：BRCA1作为乳腺癌关键蛋白参与了乳腺癌和卵巢癌的发生,本文对BRCA1基本特性进行了初步的分析,通过分析其整体的亲疏水性,氨基酸组成,表明BRCA1倾向是核蛋白,整体呈亲水性。使用PSORT2分析工具对BRCA1亚细胞定位进行预测,表明BRCA1蛋白主要分布在细胞核中。利用MEGA软件进行BRCA1系统发育分析,结果表明人BRCA1与猿的BRCA1亲缘关系高度相近。最后,采用同源建模(比较建模)方法构建了BRCA1蛋白的三级结构,从建模质量评估显示预测结果准确。BRCA1,as a key protein in breast cancer,is involved in the occurrence of breast cancer and ovarian cancer.This paper makes a preliminary analysis of the basic characteristics of BRCA1.By analyzing its overall hydrophilicity and hydrophobicity and amino acid composition,it shows that BRCA1 tends to be nucleoprotein and overall shows hydrophilic.By using PSORT2 analysis tool to carry out the prediction on the location of BRCA1 subcells,it indicats that BRCA 1 protein is mainly distributed in the nucleus.By making phylogenetic analysis of BRCA1 using MEGA software,it showed that the genetic relationship between human BRCA1 and ape BRCA1 was highly similar.Finally,the three-level structure of BRCA1 protein was constructed by the method of homologous modeling(comparative modeling),and the prediction results were accurate from the modeling quality evaluation.

关 键 词：BRCA1蛋白 三级结构预测 亚细胞定位预测 系统发育分析 

分 类 号：R[医药卫生]