小鼠应激抑郁模型建立研究进展  

The Establishment of Stress and Depression Model in Mice: A Review

作　　者：王嘉南 杨晶金[1] WANG Jia′nan;YANG jingjin(School of Medicine,Taizhou University,Taizhou 318000,Zhejiang,China)

机构地区：[1]台州学院医学院,浙江台州318000

出　　处：《台州学院学报》2018年第6期64-68,74,共6页Journal of Taizhou University

基　　金：浙江省高校境外培训项目[JW2016005];台州市科技局项目资助(1501KY31);台州学院校立项目青年基金(2016QN007)

摘　　要：抑郁症动物模型是研究抑郁机制和筛选抗抑郁症药物的重要工具和有效手段,已经被越来越广泛的运用到医学研究中去。目前常用的应激抑郁动物模型有行为绝望、慢性束缚应激、慢性不可预见性温和刺激、获得性无助、新奇环境诱导食欲减退、母仔分离等,而24小时束缚应激、牙科噪声诱导抑郁是新的简单造模方式。不同的造模方式存在各自的优缺点,可以根据需要选用不同的抑郁模型。The animal model of depression is an important tool and effective means to study the mechanism of depression and the screening of antidepressant drugs.It has been used more and more widely in medical research.At present,the commonly used animal models of stress depression include behavioral despair,chronic restraint stress,chronic unpredictable mild stress,learned helplessness,novelty induced hypophagia,mother and child separation,etc.The 24-hour restraint stress and dental noise-induced depression are new and simple models.Different modeling methods have their own advantages and disadvantages,and different depression models can be selected according to needs.

关 键 词：抑郁症 强迫游泳 慢性束缚应激 慢性温和刺激 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]