醒脑静联合盐酸纳美芬治疗急性酒精中毒昏迷期患者的效果  

Effect of Xingnaojing combined with Nalmefene Hydrochloride in the treatment of coma patients with acute alcohol intoxication

作　　者：李爱莲 梁茂锦 张森 梁鉴文 梁杰培 LI Ai-lian;LIANG Mao-jin;ZHANG Sen;LIANG Jian-wen;LIANG Jie-pei(Department of Intensive Care,People′s Hospital of Luoding City in Guangdong Province,Luoding 527200,China)

机构地区：[1]广东省罗定市人民医院重症医学科,广东罗定527200

出　　处：《中国当代医药》2019年第3期35-37,共3页China Modern Medicine

摘　　要：目的研究醒脑静联合盐酸纳美芬治疗急性酒精中毒昏迷期的效果。方法选取2017年7月～2018年5月我院收治的82例急性酒精中毒昏迷期患者作为研究对象,随机分为对照组(41例)和实验组(41例)。对照组仅使用盐酸纳美芬治疗,实验组使用醒脑静与盐酸纳美芬联合治疗。比较两组的临床治疗效果、症状恢复时间及氧化应激反应情况。结果实验组的治疗总有效率为95.12%,高于对照组的80.49%(P<0.05);实验组的神志清醒时间、症状消失时间均短于对照组(P<0.05);用药后,两组丙二醛(MDA)水平均下降,超氧歧化酶(SOD)水平均上升,且实验组MDA低于对照组,SOD高于对照组(P<0.05)。结论醒脑静联合盐酸纳美芬治疗急性酒精中毒昏迷的临床效果确切,明显缩短了患者神志清醒、症状消失的时间,减轻了氧化应激反应,值得临床推广。Objective To study the effect of Xingnaojing combined with Nalmefene Hydrochloride in the treatment of coma patients with acute alcohol intoxication.Methods A total of 82 cases of patients with acute alcohol intoxication in coma treated in our hospital from July 2017 to May 2018 were selected as the subjects,and randomly divided into control group(41 cases)and experimental group(41 cases).The group was only treated with Nalmefene Hydrochloride,and the experimental group was treated with Xingnaojing combined with Nalmefene Hydrochloride.The clinical treatment effect,symptom recovery time and oxidative stress response were compared between the two groups.Results The total effective rate of the experimental group was 95.12%,which was higher than that of the control group(80.49%)(P<0.05).The conscious time and disappearance time of the experimental group were shorter than those of the control group(P<0.05).After the medication,the MDA level of the two groups decreased,and the SOD level increased,and the MDA in the experimental group was lower than that in the control group,SOD in the experimental group was higher than that in the control group(P<0.05).Conclusion The clinical treatment effect of xingnaojing combined with naomefen hydrochloride in the treatment of acute alcohol intoxication coma is definite,which significantly shortens the patients′mental sobriety and symptom disappearance time,reduces the oxidative stress reaction,and is worthy of clinical promotion.

关 键 词：醒脑静 盐酸纳美芬 急性酒精中毒 昏迷期 治疗效果 症状恢复时间 氧化应激反应 

分 类 号：R743.2[医药卫生—神经病学与精神病学]