血清补体C3、C4水平与年龄相关性白内障的关系  

Relationship between serum complement levels of C3 and C4 and the age related cataract

作　　者：吴晓强[1] 曾俊 WU Xiaoqiang;ZENG Jun(Department of Ophthalmology,The Third People’s Hospital of Zigong City,Sichuan,Zigong 643020,China)

机构地区：[1]四川省自贡市第三人民医院眼科,643020

出　　处：《河北医药》2019年第2期174-177,共4页Hebei Medical Journal

基　　金：四川省卫生厅科研课题项目(编号:140062)

摘　　要：目的探讨年龄相关性白内障(ARC)患者血清补体C3、C4水平,并分析C3、C4与ARC的关系。方法选择收治的ARC患者267例(ARC组),其中,核性白内障患者100例,皮质性白内障患者71例,后囊膜下白内障患者96例。另取同期体检者200例作为对照组。采用免疫散射比浊法检测血清补体C3和C4水平。采用受试者工作特征曲线(ROC)分析患者入院时血清补体C3和C4水平对ARC的预测价值。结果与对照组相比,ARC组患者血清补体C3和C4水平均显著降低(P <0. 05)。核性白内障患者血清C3、C4水平最低,其次是皮质性白内障和后囊膜下白内障患者,3组比较差异均有统计学意义(P <0. 05)。补体C3对AMI患者诊断的AUC为0. 785(P <0. 01),敏感性为0. 835,特异性为0. 674;补体C4对AMI患者诊断的AUC为0. 736(P <0. 01),敏感性为0. 819,特异性为0. 577;补体C3对ARC的预测价值优于补体C4。Logistic回归分析发现,补体C3、补体C4均是ARC发生的危险因素(P <0. 05)。结论 ARC患者血清补体C3、C4水平显著降低,且与ARC类型有关,补体系统可能与ARC发病机制有关,对ARC具有一定诊断价值。Objective To investigate the serum complement levels of C3 and C4 in patients with age related cataract(ARC),and to analyze the relationship between C3,C4 and ARC.Methods A total of 267 patients with ARC who were admitted and treated in our hospital were enrolled in the study,in whom,there were 100 cases of nuclear cataract,71 cases of cortical cataract and 96 cases of posterior subcapsular cataract.At the same time the other 200 healthy subjects who received physical examination in our hospital were enrolled as control group.The serum complement levels of C3 and C4 were measured by immune nephelometry.The receiver operating characteristic curve(ROC)was used to analyze the predictive value of serum complement levels of C3 and C4 for ARC on admission.Results The serum complement levels of C3 and C4 were significantly decreased in ARC group,as compared with those in control group(P<0.05).The serum levels of C3 and C4 were the lowest in patients with nuclear cataract,next in patients with cortical cataract and patients with posterior subcapsular cataract,there were significant differences among the three groups(P<0.05).The AUC of complement C3 in diagnosis of AMI was 0.785(P<0.01),with sensitivity being 0.835 and specificity being 0.674.The AUC of complement C4 in diagnosis of AMI was 0.736(P<0.01),with sensitivity and specificity being 0.819,0.577,respectively.The predictive value of complement C3 for ARC was superior to that of complement C4.Logistic regression analysis showed that both complement C3 and complement C4 were the risk factors for ARC occurrence(P<0.05).Conclusion The serum complement levels of C3 and C4 are significantly decreased in patients with ARC,which are related to the type of ARC.The complement system may be related to the pathogenesis of ARC,which has a certain diagnostic value for ARC.

关 键 词：年龄相关性白内障 补体系统 补体C3 补体C4 

分 类 号：R776.1[医药卫生—眼科]