Naa10基因与肿瘤相关性的研究进展  

Progress of Acetyltransferase Gene Naa10 in Cancer

作　　者：何祖坤 邱有玉 白松[1] 杨红菊[1] HE Zukun;QIU Youyu;BAI Song;YANG Hongju(Department of Elderly General Surgery,First Affiliated Hospital of Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学第一附属医院老年普外科,昆明650500

出　　处：《肿瘤防治研究》2019年第1期76-80,共5页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金(81660410);云南省科技计划项目(2017FE468-174)

摘　　要：N-末端α位乙酰基转移酶基因10(Naa10)广泛存在于真核生物细胞中,其编码的Naa10p是NatA复合物的催化亚基。Naa10p修饰新生蛋白质N末α位氨基酸残基乙酰化,进而通过介导mTOR、Ca^(2+)/MLCK、DNMT1、PGK1、PIX-蛋白等信号通路调控蛋白降解、细胞凋亡、增殖、迁移、浸润、血管生成等生物学过程。根据乙酰化底物的不同,Naa10p还在细胞凋亡的调控中起双重作用。研究发现Naa10p在肝癌、结直肠癌、乳腺癌、肺癌、前列腺癌等多种癌组织中过表达,而在癌旁组织中不表达或低表达,因肿瘤差异其预后意义不同。因此,Naa10可作为部分肿瘤诊断和预后的新型潜在生物标志物及治疗靶点。N-α-terminal acetyltransferase gene 10(Naa10)is extensively expressed in eukaryotic cells,and its encoded Naa10p is the catalytic subunit of the NatA complex.Naa10p modifies the acetylation of aminophenol residues at the N-terminal-αof nascent protein;it regulates the biological processes such as protein degradation,apoptosis,cell proliferation,cell migration,infiltration and angiogenesis by mediating mTOR,Ca2+/MLCK,DNMT1,PGK1 and PIX-protein pathways.Depending on the acetylated substrate,Naa10p also plays a dual role in the regulation of apoptosis.In the present studies,Naa10p is over-expressed in various cancer tissues such as liver cancer,colorectal cancer,breast cancer,lung cancer and prostate cancer,etc.;contrarily,low or non-expressed in paracancerous tissues.It correlates to diverse prognosis of different cancers.Therefore,it could be considered as a novel potential biomarker and therapeutic target for the diagnosis and prognosis of some cancers.

关 键 词：N-末端α位乙酰基转移酶基因10 乙酰转移酶 肿瘤 

分 类 号：R730[医药卫生—肿瘤]