溶血磷脂酸在动脉粥样硬化病变中的作用  

The Effects of Lysophosphatidic Acid in Atherosclerotic Lesion

作　　者：张建平[1] 李亚峰 郭庚[1] ZHANG Jian-Ping;LI Ya-Feng;GUO Geng(Department of Neurosurgery,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Nephrology,Shanxi Provincial People’s Hospital,Taiyuan 030012,China)

机构地区：[1]山西医科大学第一医院神经外科,太原030001 [2]山西省人民医院肾内科

出　　处：《中国卒中杂志》2018年第12期1277-1281,共5页Chinese Journal of Stroke

基　　金：国家自然科学基金(81201991);中国博士后科学基金(2015M571068;2016T90115);北京博士后工作经费资助项目(2015ZZ56);山西省高等学校创新人才支持计划(晋教科[2013]8号)

摘　　要：动脉粥样硬化是一种严重的慢性动脉炎症性疾病,可以引起冠状动脉粥样硬化性心脏病和缺血性卒中等疾病。溶血磷脂酸在动脉粥样硬化的发生发展过程中起着至关重要的作用,它通过对血管内皮细胞、血管平滑肌细胞、单核-巨噬细胞、成纤维细胞、树突状细胞、T淋巴细胞及血小板等发挥作用促进动脉粥样硬化和血栓形成。探讨溶血磷脂酸在动脉粥样硬化发展中的作用和相关病理生理机制有助于探索抗动脉粥样硬化的潜在药物和干预措施。Atherosclerosis is a severe and chronic inflammatory arterial disease that can lead to coronary heart disease,ischemic stroke and etc.Lysophosphatidic acid(LPA)plays a crucial role in the progression of atherosclerotic lesion by acting on endothelial cells,vascular smooth muscle cells,monocytes/macrophages,fibroblasts,dendritic cells,T-lymphocytes and platelets,which promotes atherosclerosis and thrombosis.Studies on the effects and pathophysiologic mechanisms of LPA in the atherosclerosis can contribute to find potential drugs and prevention measures for anti-atherosclerosis.

关 键 词：溶血磷脂酸 动脉粥样硬化 血栓形成 内皮细胞 

分 类 号：R743[医药卫生—神经病学与精神病学] R543.5[医药卫生—临床医学]