Postprandial hyperglycemia and postprandial hypertriglyceridemia in type 2 diabetes  

作　　者：Toru Hiyoshi Mutsunori Fujiwara Zemin Yao 

机构地区：[1]Division of Diabetes and Endocrinology,Department of Internal Medicine, Japanese Red Cross Medical Center [2]Department of Laboratory Medicine, Japanese Red Cross Medical Center [3]Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology,University of Ottawa

出　　处：《The Journal of Biomedical Research》2019年第1期1-16,共16页生物医学研究杂志（英文版）

摘　　要：Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Several therapeutic approaches for ameliorating each of these abnormalities have been attempted, including various antidiabetic agents or new compounds targeting lipid metabolism.Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Several therapeutic approaches for ameliorating each of these abnormalities have been attempted, including various antidiabetic agents or new compounds targeting lipid metabolism.

关 键 词：POSTPRANDIAL HYPERGLYCEMIA POSTPRANDIAL HYPERTRIGLYCERIDEMIA Type 2 DIABETES MELLITUS ATHEROSCLEROSIS 

分 类 号：R587[医药卫生—内分泌]