KIAA1199基因在消化系统肿瘤中的作用  

Role of KIAA1199 Gene in Digestive System Neoplasms

作　　者：董晴晴[1] 邹慧敏 朱黎明[1] DONG Qingqing;ZOU Huimin;ZHU Liming(Department of Gastroenterology,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,Shanghai 201900)

机构地区：[1]上海交通大学医学院附属第九人民医院消化科,201900

出　　处：《胃肠病学》2019年第1期51-53,共3页Chinese Journal of Gastroenterology

基　　金：上海交通大学医学院科技基金(14XJ10066)

摘　　要：KIAA1199基因是HUGE数据库中的重要成员之一,通过表观遗传学等机制参与细胞内信号通路的转导,调控细胞生长、分化、凋亡、迁移等活动。近年研究发现,KIAA1199基因与肿瘤的发生、发展关系密切,在人类多种肿瘤尤其是消化系统肿瘤中的表达均异常升高,具有促进肿瘤细胞增殖、黏附、侵袭、迁移等作用。本文就KIAA1199基因在消化系统肿瘤中的作用作一综述。KIAA1199 gene is an important member of the HUGE database,and is involved in the transduction of intracellular signaling pathway through epigenetic mechanism,regulating the cell growth,differentiation,apoptosis and migration.Recent studies showed that KIAA1199 gene is closely related to tumorigenesis and tumor development.The expression of KIAA1199 gene is highly upregulated in many types of tumor,especially in digestive system neoplasms,and having the effects of promoting proliferation,adhesion,invasion and migration of tumor cells.This article reviewed the role of KIAA1199 gene in digestive system neoplasms.

关 键 词：KIAA1199基因 消化系统肿瘤 细胞增殖 细胞迁移 

分 类 号：R735[医药卫生—肿瘤]