31例抗线粒体M2亚型抗体表达阴性原发性胆汁性肝硬化患者的临床特点  

Clinical features of 31 primary biliary cirrhosis patients with negative AMA-M2 subtype

作　　者：张春来[1] 冯慧[1] 秦臻 张恒[1] 郭绪晓[1] ZHANG Chunlai;FENG Hui;QIN Zhen;ZHANG Heng;GUO Xuxiao(Department of Laboratory Medicine,Affiliated Hospital of Shan- dong University of Traditional Chinese Medicine,Jinan 250011,China)

机构地区：[1]山东中医药大学附属医院检验科,济南250011

出　　处：《实用医学杂志》2019年第2期307-310,共4页The Journal of Practical Medicine

基　　金：山东省中医药科技发展计划项目资助项目(编号:2015-079)

摘　　要：目的研究31例抗线粒体M2亚型抗体(AMA-M2)阴性原发性胆汁性肝硬化(PBC)患者临床特征,为疾病的临床诊治提供帮助。方法收集2010年3月1日至2018年6月31日在山东中医药大学附属医院诊为PBC的158例病例,31例表达阴性者为病例组,127例表达阳性者为对照组,比较两组各指标有无统计学差异。结果病例组女性占28例(90.3%),临床表现主要为乏力、瘙痒、黄疸等,血清生物化学检查指标主要表现为碱性磷酸酶及谷氨酰转肽酶明显升高,以上指标均与对照组无明显统计学差异;血清免疫学检查指标中抗核抗体、抗M2-3E抗体表达阳性率高于对照组,差异有统计学意义(P <0.05),抗Sp100抗体等其他指标差异无统计学意义(P> 0.05)。结论病例组在临床表现、生化检查指标方面与对照组无明显差异,而抗核抗体等相关自身抗体检测及肝脏组织病理学检查可作为抗体表达阴性患者诊断PBC的有效指标。Objective To analyze the clinical features of primary biliary cirrhosis patients with negative anti-mitochondria antibody M2 subtype,and to provide the scientific basis for diagnosis of PBC.Methods From March 2010 to August 2018,158 patients hospitalized for primary biliary cirrhosis at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine were enrolled in this study,including 31 negative cases and 127 positive cases.The clinical manifestation and laboratory test of cases with PBC were retrospectively analyzed between the two groups.Results In the negative group,28(90.3%)patients were female,and 119(93.7%)pa tients were female in the positive group.The main symptoms and signs of these patients were fatigue,pruritus and jaundice.The main features of serum biochemical parameters of these patients included the increase of alkaline phosphatase and gamma glutamyltranspeptidase,without significant differences between the AMA-M2 positive group and the negative group.The positive rates of ANA,M2-3E in the negative group were higher than those in the positive group.There were significant differences in the positive rates of those immunological parameters be tween the two groups(P<0.05,respectively).Conclusion The differences in the clinical features and serum biochemical parameters between the AMA-M2 positive and negative groups were not statistically significan.The anti-nuclear antibody test and liver pathological examination play important roles in diagnosis of PBC patients of the negative AMA-M2 subtype.

关 键 词：AMA-M2 原发性胆汁性肝硬化 抗线粒体抗体 抗核抗体 

分 类 号：R575.2[医药卫生—消化系统]