地黄饮子方结合胞磷胆碱治疗血管性痴呆肾精亏虚兼痰瘀阻络证疗效及对血清β-AP、E_2、Livin水平的影响  

Curative effect of Dihuangyinzi Decoction combined with citicoline on vascular dementia of syndrome of renal deficiency plus phlegm-stasis obstruction and its effect on serum β-AP,E_2 and Livin levels

作　　者：覃辉 周城恩[2] 陆晖 江颖[2] 张永全[2] QIN Hui;ZHOU Chengen;LU Hui;JIANG Ying;ZHANG Yongquan(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,Guangxi,China)

机构地区：[1]天津中医药大学,天津300193 [2]广西中医药大学附属瑞康医院,广西南宁530011

出　　处：《现代中西医结合杂志》2019年第6期589-592,596,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察地黄饮子方结合胞磷胆碱治疗血管性痴呆肾精亏虚兼痰瘀阻络证疗效及对血清β淀粉样蛋白(β-AP)、雌二醇(E2)及抗凋亡因子(Livin)水平的影响。方法将96例血管性痴呆肾精亏虚兼痰瘀阻络证患者随机分为观察组和对照组各48例。对照组给予胞磷胆碱钠胶囊口服治疗,观察组给予地黄饮子方结合胞磷胆碱钠胶囊治疗。治疗3个月后,对比2组认知功能(记忆力、定向力、计算力和注意力、语言能力、MMSE总分)、生活自理能力(ADL评分)、精神病理症状(NPI评分)及血清β-AP、E2、Livin水平的改善情况,并评估临床疗效。结果观察组治疗后总有效率明显高于对照组(P <0. 05); 2组MMSE总分,记忆力、定向力、计算力和注意力、语言能力积分,E2水平、Livin水平及ADL评分均显著升高(P均<0. 05),NPI评分和β-AP水平均显著降低(P均<0. 05),且观察组治疗后上述指标改善程度更为明显(P均<0. 05)。结论地黄饮子方结合胞磷胆碱治疗血管性痴呆肾精亏虚兼痰瘀阻络证,能够有效改善患者的认知功能、生活自理能力、精神病理状态以及血清β-AP、E2和Livin表达水平,疗效确切。Objective It is to observe the therapeutic effect of Dihuangyinzi Decoction combined with citicoline on vascular dementia of syndrome of renal deficiency plus phlegm-stasis obstruction,and its effect on the levels of serumβamyloid protein(β-AP),estradiol(E 2)and anti-apoptotic factor(Livin).Methods Ninety-six patients with vascular dementia with kidney essence deficiency and phlegm obstruction syndrome were randomly divided into observation group and control group.The control group was treated with citicoline sodium capsules orally,and the observation group was given Dihuangyinzi Decoction combined with citicoline sodium capsules.After 3 months of treatment,the improvements of cognitive function(memory,orientation,calculation and attention,language ability,MMSE total score),self-care ability(ADL score),psychopathological symptoms(NPI score)and serumβ-AP,E 2 and Livin levels were compared,and the clinical curative effects were assessed in the two gorups.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The MMSE total scores,the scores of memory,orientation,calculation and attention,language ability,levels of E 2 and Livin,and ADL scores were significantly increased(P<0.05),while NPI scores andβ-AP level were significantly decreased in the two groups(P<0.05),and the improvements of the above indicators were more obvious in the observation group(P<0.05).Conclusion Dihuangyinzi combined with citicoline can effectively improve the cognitive function,self-care ability,psychopathological state and the levels of serumβ-AP,E 2 and Livin in the treatment of vascular dementia with renal essence deficiency and phlegm obstruction syndrome,the curative effect is exact.

关 键 词：血管性痴呆 肾精亏虚兼痰瘀阻络证 地黄饮子方 胞磷胆碱 认知功能 

分 类 号：R742[医药卫生—神经病学与精神病学]