阿托伐他汀钙治疗急性缺血性脑梗死的临床疗效及对血浆溶血磷脂酸水平的影响  

Effect of atorvastatin calcium on plasma lysophosphatidic acid levels in patients with acute ischemic cerebral infarction

作　　者：王洋 刘建祥 陶国辉 余建华 马鸿 WANG Yang;LIU Jian-xiang;TAO Guo-hui(One department of Medicince,the Affiliated Hospital of Shaoguan University, Shaoguan 512025,China;Department of medicine, Yuebei Hospital,Shaoguan 512025,China;Shaoguan College of Medicine , Shaoguan 512025,China)

机构地区：[1]韶关学院附属医院内一科,广东韶关512025 [2]粤北医院内科,广东韶关512025 [3]韶关学院医学院,广东韶关512025

出　　处：《吉林医学》2019年第2期210-212,共3页Jilin Medical Journal

摘　　要：目的:研究阿托伐他汀钙对急性缺血性脑梗死的治疗效果及血浆溶血磷脂酸(LPA)水平的影响。方法:随机数字法将96例急性缺血性脑梗死患者分为观察组与对照组,各48例。对照组给予常规治疗,观察组在对照组基础上加以阿托伐他汀钙治疗。比较两组临床疗效、治疗前后NIHSS评分、血脂指标、血浆LPA水平及血清炎性反应因子变化,评价治疗安全性。结果:观察组治疗总有效率为93. 75%,对照组为77. 08%,差异有统计学意义(P <0. 05)。观察组治疗后NIHSS评分、血浆LPA水平分别为(12. 34±1. 15)分、(2. 16±0. 78)μmol/L,对照组分别为(15. 59±1. 20)分、(3. 69±1. 00)μmol/L,两组比较差异有统计学意义(P <0. 05)。与治疗前比较,两组治疗后TC、LDL-C、血清hs-CRP、IL-6、TNF-α水平均显著下降,差异均有统计学意义(P <0. 05),且观察组治疗后上述指标均显著低于对照组,差异均有统计学意义(P <0. 05)。两组均无肝肾功能异常情况和恶心、呕吐等不良反应发生。结论:阿托伐他汀钙治疗急性缺血性脑梗死效果较好,能明显改善患者神经功能缺损症状,这可能与阿托伐他汀钙调脂、降低血浆LPA水平、抑制炎性反应有关。Objective To study the effects of atorvastatin in the treatment of acute ischemic cerebral infarction and the effect on plasma lysophosphatidic acid( LPA) level. Method 96 cases of patients with acute ischemic cerebral infarction were randomly divided into the observation group and the control group by random number table method. 48 cases in each group. The control group were given routine treatment,and the observation group were additionally treated with atorvastatin. The clinical efficacy,NIHSS scores before and after treatment,serum lipids,plasma LPA levels and serum inflammatory factors were compared between the two groups. The treatment safety was evaluated. Results The total effective rate of treatment in the observation group was 93. 75% while in the control group was 77. 08%,the difference was statistically significant( P < 0. 05). After treatment,the NIHSS score and plasma LPA level showed significant differences between the observation group than the control group[( 12. 34± 1. 15),( 2. 16 ± 0. 78)μmol/L vs( 15. 59 ± 1. 20),( 3. 69 ± 1. 00)μmol/L]( P < 0. 05). After treatment,levels of TC,LDL-C,serum hs-CRP,IL-6 and TNF-α in the two groups were significantly lower than those before treatment( P <0. 05),and the above levels were significantly lower in the observation group than the control group( P < 0. 05). There were no adverse reactions such as abnormal liver and kidney function,nausea and vomiting in the two groups. Conclusion Atorvastatin is effective in the treatment of acute ischemic cerebral infarction. It can significantly relieve symptoms of neurologic impairment,which may be related to atorvastatin regulating lipids,decreasing plasma LPA level and inhibiting inflammatory reactions.

关 键 词：急性缺血性脑梗死 阿托伐他汀钙 血浆溶血磷脂酸 炎性反应因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]