MR弥散张量成像对缺氧缺血性脑病的Meta分析报告  

Meta-analysis of MR Diffusion Tensor Imaging for Hypoxic-Ischemic-cephalopathy

作　　者：党保华[1] 赵鑫[1] 宋娟[1] 张小安[1] DANG Bao-hua;ZHAO Xin;SONG Juan(Department of Radiology,The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China)

机构地区：[1]郑州大学第三附属医院放射科,河南郑州450052

出　　处：《中国CT和MRI杂志》2019年第1期1-5,共5页Chinese Journal of CT and MRI

摘　　要：目的采用Meta分析综合定量评价MR弥散张量成像对缺氧缺血性脑病的诊断价值。方法检索美国医学索引Medline、Ovid、Springer、Elsevier、LippincottWilliams&Wilkins(Lww)数据库及中国期刊网国内文献库(CNKI)1997年1月至2016年12月公开发表的中英文文献,分析软件为RevMan5.3,合并效应量为加权均数差(weightedmean difference,WMD)。结果纳入研究DTI诊断HIE的文献共13篇。结果显示:(1)轻、中、重度HIE组新生儿内囊后肢、胼胝体膝部、压部各向异性分数(fractional anisotropy,FA)值比对照组新生儿低,其中内囊后肢WMD及95%CI为-0.04(-0.06,-0.02)、-0.07(-0.10,-0.03)、-0.07(-0.10,-0.03);胼胝体压部WMD及95%CI为-0.09(-0.10,-0.07)、-0.09(-0.12,-0.06)、-0.19(-0.33,-0.05);胼胝体膝部WMD及95%CI为-0.06(-009,-0.03)、-0.07(-0.10,-0.05)、-0.13(-0.21,-0.06)。(2)轻度HIE组新生儿在顶叶白质、额叶白质区FA值与对照组新生儿相比无统计学意义;中重度组FA值比对照组新生儿低。(3)豆状核、丘脑、尾状核及放射冠区FA值与对照组新生儿相比无统计学意义。结论内囊后肢、胼胝体压部及膝部是HIE受累最明显的部位;其FA值降低可为HIE的早期诊断提供影像学依据。Objective To evaluate the value of MR diffusion tensor imaging in the diagnosis of hypoxic-ischemic-cephalopathy by Meta-analysis.Methods Searching the related literatures in Medline,Ovid,Springer,Elsevier,Lippincott Williams&Wilkins(Lww)and the Chinese Journal Net(CNKI)from January 1997 to December 2016,analysis software for the RevMan 5.3,the combined effect was the weighted average difference(WMD).Results A total of 13 articles were included in the study of DTI diagnosis of HIE.The results showed that:(1)The FA value of the posterior limb of internal capsule,the plenium and genu of corpus callosum in the neonates with mild,moderate and severe HIE were lower than that in the control group of which the value of WMD and 95%CI in the posterior limb of Internal capsule were-0.04(-0.06,-0.02),-0.07(-0.10,-0.03),-0.07(-0.10,-0.03),of which the value of WMD and 95%CI in the Splenium of corpus callosum were-0.09(-0.10,-0.07),-0.09(-0.12,-0.06),-0.19(-0.33,-0.05);of which the value of WMD and 95%CI in the Genu of corpus callosum were-0.06(-009,-0.03),-0.07(-0.10,-0.05),-0.13(-0.21,-0.06).(2)There was no significant difference in the FA value of the Parietal white matter,frontal white matter in neonates with mild HIE group compared with the control group.The FA value of moderate to severe group was lower than that of control group.(3)There were no statistically significant in comparing the FA value of lentiform nucleus,thalamus,caudate nucleus and radiation crown with neonatal control group.Conclusion The posterior limb of internal capsule,the splenium and genu of corpus callosum were the most obvious parts of HIE involvement.The decrease of FA value can provide imaging basis for the early diagnosis of HIE.

关 键 词：缺氧缺血性脑病 弥散张量成像 META分析 

分 类 号：R742[医药卫生—神经病学与精神病学]