Neurological functional evaluation based on accurate motions in big animals with traumatic brain injury  

作　　者：Ji-Peng Jiang Xue-Gang Niu Chen Dai Ke Ma Hui-You Xu Shi-Xiang Cheng Zhi-Wen Zhang Feng Duan Xu Zhu Yu-Ting Wang Xu-Yi Chen Sai Zhang 

机构地区：[1]Center for Neurology and Neurosurgery,Medical Center of People's Armed Policed Force,Key Laboratory of Neurotrauma Repair of Tianjin [2]Department of Neurosurgery,Tianjin Fourth Central Hospital [3]Department of Automation,College of Computer and Control Engineering,Nankai University [4]Graduate School,Tianjin Medical University

出　　处：《Neural Regeneration Research》2019年第6期991-996,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.11672332,11102235 and 31200809(all to XYC);the National Key Research and Development Plan of China,No.2016YFC1101500(to SZ);the Science and Technology Program of Tianjin,China,No.17YFZCSY00620 and 16ZXHLSY00120(both to XYC)

摘　　要：An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However,most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also difficult to use to qualify the extent of damage and recovery. In the present study, we established a big animal model of traumatic brain injury by impacting the cortical motor region of beagles. At 2 weeks after successful modeling, we detected neurological deficiencies in the animal model using a series of techniques, including three-dimensional motion capture, electromyogram and ground reaction force. These novel technologies may play an increasingly important role in the field of traumatic brain injury diagnosis and rehabilitation in the future. The experimental protocol was approved by the Animal Care and Use Committee of Logistics University of People's Armed Police Force(approval No. 2017-0006.2).An accurate and effective neurological evaluation is indispensable in the treatment and rehabilitation of traumatic brain injury. However,most of the existing evaluation methods in basic research and clinical practice are not objective or intuitive for assessing the neurological function of big animals, and are also difficult to use to qualify the extent of damage and recovery. In the present study, we established a big animal model of traumatic brain injury by impacting the cortical motor region of beagles. At 2 weeks after successful modeling, we detected neurological deficiencies in the animal model using a series of techniques, including three-dimensional motion capture, electromyogram and ground reaction force. These novel technologies may play an increasingly important role in the field of traumatic brain injury diagnosis and rehabilitation in the future. The experimental protocol was approved by the Animal Care and Use Committee of Logistics University of People's Armed Police Force(approval No. 2017-0006.2).

关 键 词：nerve REGENERATION evaluation method NEUROLOGICAL deficiency TRAUMATIC brain injury motion capture ELECTROMYOGRAM ground reaction force neural REGENERATION 

分 类 号：R443[医药卫生—诊断学] R363[医药卫生—临床医学]