肠道菌群失调对糖尿病及糖尿病肾病影响的研究进展  

Research Progress in Influence of Intestinal Flora Imbalance on Diabetes Mellitus and Diabetic Nephropathy

作　　者：王勤[1] 杨亦彬[1] WANG Qin;YANG Yibin(Zunyi Medical College,Zunyi 563000,China)

机构地区：[1]遵义医学院,贵州遵义563000

出　　处：《医学综述》2019年第3期530-534,共5页Medical Recapitulate

基　　金：国家自然科学基金(81260118)

摘　　要：肠道菌群是机体的重要组成部分,对人类健康有巨大影响。肠道菌群的组成和代谢活性发生改变可导致肠道菌群失衡,从而影响人体代谢系统的正常发展。目前已证实,肠道菌群结构和多样性的改变与炎症性肠病、心血管疾病、癌症、肥胖症、慢性炎症、血脂异常、过敏性疾病等相关。此外,肠道菌群失调在糖尿病及糖尿病肾病的发病和发展中起着重要作用,肠道菌群失衡可导致肠源性尿毒症毒素的积累、脂多糖的高循环水平、免疫失调以及胰岛素抵抗等,深入了解肠道菌群的结构、组成以及作用机制可为防治糖尿病及糖尿病肾病提供理论参考。Intestinal flora,which is an important part of the organism,has a great impact on human health.Changes in the composition and metabolic activity of intestinal flora can lead to imbalance of intestinal flora,thus affecting the normal development of human metabolic system.It has been confirmed that changes in the structure and diversity of intestinal flora are associated with inflammatory bowel disease,cardiovascular disease,cancer,obesity,chronic inflammation,dyslipidemia,allergic diseases and so on.In addition,intestinal flora imbalance plays important roles in the pathogenesis and development of diabetes and diabetic nephropathy.The imbalance of intestinal flora can lead to the accumulation of enterogenous uremic toxin,high circulating levels of lipopolysaccharide,immune disorders and insulin resistance.Therefore,an in-depth understanding of the structure,composition and action mechanism of the intestinal flora can provide a theoretical reference for the prevention and treatment of diabetes and diabetic nephropathy.

关 键 词：糖尿病 糖尿病肾病 肠道菌群 菌群失调 益生菌 益生元 

分 类 号：R587.2[医药卫生—内分泌]