53例脑胶质瘤术后放疗后的生存状况及预后因素分析  

Survival situation and prognostic factors analysis of 53 glioma patients treated with radiotherapy after surgery

作　　者：王海静[1] 赵维勇[1] 毕良文[1] 张丽珍[1] 田继红[1] WANG Hai-jing;ZHAO Wei-yong;BI Liang-wen;ZHANG Li-zhen;TIAN Ji-hong(Department of Radiotherapy,the Second Affiliated Hospital of Nanjing Medical University,Jiangsu Province,Nanjing 210011,China)

机构地区：[1]南京医科大学第二附属医院放疗科,江苏南京210011

出　　处：《中国当代医药》2019年第5期80-82,共3页China Modern Medicine

摘　　要：目的探讨脑胶质瘤患者术后放疗后的生存状况及影响预后的因素。方法回顾性分析2004年11月～2017年2月在我院诊治的53例脑胶质瘤患者的临床资料,采用Kaplan Meier法进行生存分析,采用比例风险模型(Cox模型)进行单因素、多因素分析。结果脑胶质瘤患者术后放疗后的1、2、5年生存率分别为66.0%、45.3%及24.5%,中位生存时间为20个月。单因素分析显示,年龄、KPS评分、WHO分级对生存期有影响(P<0.05)。多因素分析显示,KPS评分、WHO分级是预后的独立因素(P<0.05)。结论 KPS>70分、WHO低分级是胶质瘤患者的独立预后因素,这些患者的生存期较长,是潜在的治疗获益者。Objective To investigate the survival situation and prognostic factors of the glioma patients treated with radiotherapy after surgery.Methods The clinical data of 53 patients with glioma treated in our hospital from November 2004 to February 2017 were analyzed retrospectively.Kaplan Meier method was used for survival analysis,and Cox model was used for univariate and multivariate analysis.Results The survival rates at 1,2,5 years were 66.0%,45.3%and 24.5%,respectively.The median survival was 20 months.Univariate analysis showed that age,KPS score and WHO grade were associated with overall survival(P<0.05).Multivariate analysis indicated that KPS score and WHO grade were independent prognostic factors(P<0.05).Conclusion KPS >70 points and low WHO grade are independent prognostic factors for glioma patients.

关 键 词：脑胶质瘤 放疗 生存 预后因素 

分 类 号：R739.41[医药卫生—肿瘤]