非小细胞肺癌影像特征及病理类型联合Ki-67基因表达对术后脑转移的风险分析  

Risk Analysis Brain Metastasis of Non-small Cell Lung Cancer( NSCLC) in Combinationwith Image Feature、Pathological Pattern and Ki-67 Gene Expression

作　　者：胡利平[1] 邹飞[1] 方常练[1] 王索宇[1] 黄传生[1] 黄先明[1] 黄建[1] 江峰[1] 刘敏知[1] 徐炎良[1] HU Liping;ZOU Fei;FANG Changlian(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2019年第2期219-222,共4页The Practical Journal of Cancer

基　　金：江西省卫生计生委科技计划项目(编号:20151108)

摘　　要：目的探讨非小细胞肺癌的影像特征、病理类型及其Ki-67抗原表达与术后是否发生脑转移的相关性。方法回顾并追踪随访经手术病理证实的非小细胞肺癌患者110例,所有患者术前均行胸部及颅脑影像学检查、术后明确病理类型并完善标本免疫组化Ki-67检测;术后随访未发生脑转移组83例,发生脑转移组27例。结果 Ki-67表达水平发生脑转移组较未发生脑转移组明显升高,肺部原发肿瘤的大小、形态、胸内淋巴结状态及病理类型在脑转移组与无脑转移组之间存在明显差异,应用Logistic回归分析显示肿瘤的大小、形态、胸内淋巴结状态及病理类型是脑转移的危险因素。结论原发肺部肿瘤的大小、形态、胸内淋巴结状态、病理类型及Ki-67抗原表达与术后脑转移的发生密切相关。Objective To explore whether certain imaging features,histologic subtypes and ki-67 expression in patients with non-small-cell lung cancer is associated with a higher rate of brain metastases after surgery.Methods A total of 110 patients including 27 cases with primary lung tumor and brain metastasis and 83 control cases with primary lung tumor but no brain metastasis were resected and underwent chest and brain imaging,pathological analysis and immunohistochemical expression of ki-67.Results The gender,age,primary lung tumor location,CT value have no obvious difference between the two groups,while that of the primary tumor size,shape,intrathoracic lymph node status,histological type,Ki-67 antigen expression level make significant contribution for brain metastasis.Multiple factors analysis showed that large tumor,intrathoracic lymph node positive,non squamous cell carcinoma and high Ki-67 expression are risk factors for brain metastases.Conclusion The size of primary lung tumor、status of intrathoracic lymph nodes、pathological type and expression of ki-67 antigen were closely related to the occurrence of postoperative brain metastasis.

关 键 词：非小细胞肺癌 影像 病理 KI67 脑转移 

分 类 号：R734.2[医药卫生—肿瘤]