经尿道钬激光膀胱肿瘤切除术与电切术对非肌层浸润性膀胱癌的疗效对比  

Transurethral Holmium Laser Bladder Tumor Resection vs Transurethral Resection of Bladder Tumor for Non-muscular Invasive Bladder Carcinoma

作　　者：雷超[1] 廖凯[1] 董文瑞[1] LEI Chao;LIAO Kai;DONG Wenrui(The First People's Hospital of Guangyuan City,Guangyuan,628017)

机构地区：[1]四川省广元市第一人民医院,628017

出　　处：《实用癌症杂志》2019年第2期296-299,共4页The Practical Journal of Cancer

摘　　要：目的分析经尿道钬激光膀胱肿瘤切除术对比经尿道膀胱肿瘤电切术对非肌层浸润性膀胱癌临床疗效。方法选取接受手术治疗的非肌层浸润性膀胱癌患者共182例,依据随机数字表法随机分为研究组和对照组各91例,研究组给予经尿道钬激光膀胱肿瘤切除术治疗,对照组患者采用经尿道膀胱肿瘤电切术治疗,对比两组患者的治疗效果。结果研究组患者的手术时间[(19. 35±11. 82) min]显著低于对照组[(29. 26±15. 25) min],术中出现闭孔神经反射和膀胱穿孔的例数均显著低于对照组,差异有统计学意义(P <0. 05);研究组患者的留置尿管时间[(3. 5±1. 26) d]、术后住院时间[(4. 1±0. 98) d]及总住院费用[(1. 26±0. 25)万元]均显著少于对照组[(7. 6±2. 23d)、(8. 6±1. 35) d、(1. 43±0. 32)万元],差异有统计学意义(P <0. 05);两组术后出血例数及术后复发例数对比,差异无统计学意义(P>0. 05);治疗后,研究组MMP-9 [(427. 33±71. 23)μg/L]与VEGF水平[(839. 81±193. 62) ng/L]均显著低于对照组[(586. 16±69. 82)μg/L和(986. 56±177. 23) ng/L],差异有统计学意义(P <0. 05);两组患者治疗后MMP-9与VEGF水平较治疗前均显著降低,差异有统计学意义(P <0. 05)。结论经尿道钬激光膀胱肿瘤切除术相对于经尿道膀胱肿瘤电切术不仅操作便捷,手术创伤小,还取得了更好的治疗效果,缩短了患者的住院时间,降低了治疗成本,值得在临床进行广泛推广。Objective To analyze the clinical effect of transurethral holmium laser bladder tumor resection versus transurethral resection of bladder tumor on non-muscle invasive bladder cancer.Methods A total of 182 patients with non-muscle invasive bladder cancer who underwent surgery were randomly divided into study group(91 cases)and control group(91 cases)according to the random number table Group was given transurethral holmium laser bladder tumor resection for treatment,the control group of patients with transurethral resection of the bladder tumor,compared the treatment effect of two groups of patients.Results The operation time of the study group(19.35±11.82)min was significantly lower than that of the control group(29.26±15.25)min.The number of obstructive nerve reflex and bladder perforation in the study group was significantly lower than that of the control group Significance(P<0.05);The duration of indwelling catheter(3.5±1.26)days,postoperative hospital stay(4.1±0.98)days and total hospitalization cost(1.26±0.25)million in study group were significantly less than those in control group(7.6±2.23)days,(8.6±1.35)d,(1.43±0.32)respectively,the difference was statistically significant(P<0.05);There was no significant difference between the two groups in the number of postoperative bleeding and postoperative recurrence(P >0.05).After treatment,the levels of MMP-9(427.33±71.23)μg/L and VEGF(839.81±193.62)ng/L in the study group were significantly lower than those in the control group(586.16±69.82)μg/L and(986.56±177.23)ng/L There was statistical significance(P<0.05);The levels of MMP-9 and VEGF in both groups after treatment were significantly lower than those before treatment,the difference was statistically significant(P<0.05).Conclusion Transurethral resection of holmium laser bladder tumor compared with transurethral resection of bladder tumor is not only easy to operate,less trauma,but also achieved better therapeutic effect,shorten the hospitalization time and reduce the cost of treatment,it is wort

关 键 词：钬激光 膀胱癌 非肌层浸润性 电切术 

分 类 号：R737.14[医药卫生—肿瘤]