Ⅰ期宫颈癌患者化疗前外周血中TSGF、SCC-Ag、CA125水平表达对其预后的评估价值  

Evaluation of the Expression of TSGF,SCC-Ag and CA125 in Peripheral Blood of Patients with Cervical Cancer before Chemotherapy

作　　者：刘月芬[1] LIU Yuefen(The General Hospital of Oil Field in Puyang,Puyang,457001)

机构地区：[1]河南省濮阳市油田总医院,457001

出　　处：《实用癌症杂志》2019年第2期321-323,共3页The Practical Journal of Cancer

摘　　要：目的探究宫颈癌患者化疗前外周血中TSGF、SCC-Ag、CA125表达水平对其预后的评估价值。方法选取Ⅰ期宫颈癌患者70例,并在治疗结束后随访3年,记录患者肿瘤复发的情况,比较不同预后情况患者化疗前外周血中TSGF、SCC-Ag、CA125表达水平,分析上述指标对不同预后的评估价值。结果 3年无复发的患者化疗前外周血中TS-GF、SCC-Ag、CA125表达水平[(54. 63±12. 35) U/ml、(2. 42±0. 60)μg/L、(27. 28±12. 28) U/ml]明显低于复发患者的[(78. 29±18. 29) U/ml、(3. 89±1. 25)μg/L、(36. 43±13. 05) U/ml](P <0. 05)。通过Spearman相关性分析显示,患者化疗前外周血中TSGF、SCC-Ag、CA125表达水平与治疗后3年内复发风险呈正相关(γ=0. 535、γ=0. 329、γ=0. 744,P <0. 05);进一步受试者操作特性曲线(ROC)分析结果显示,宫颈癌患者化疗前对外周血中TSGF、SCC-Ag、CA125表达水平联合预测其3年内肿瘤复发的敏感度、特异度及准确性均较高。结论早期宫颈癌患者化疗前外周血中TSGF、SCC-Ag、CA125表达水平可作为患者预后评估的指标。Objective To evaluate the prognostic value of TSGF,SCC-Ag and CA125 in peripheral blood of patients with cervical cancer before chemotherapy.Methods 70 patients with cervical cancer diagnosed withⅠ~Ⅱwere enrolled in our hospital from January 2013 to January 2014 and were followed up for 3 years after the end of treatment.The recurrence of tumor was recorded and the patients were treated with different prognosis.The expression levels of TSGF,SCC-Ag and CA125 in peripheral blood were detected before and after treatment.The prognostic value of these indexes was analyzed.Results The expression levels of TSGF,SCC-Ag and CA125 in peripheral blood of patients without recurrence(54.63±12.35 U/ml、2.42±0.60μg/L、27.28±12.28 U/ml)were significantly lower than those in patients with relapse after three years(78.29±18.29 U/ml、3.89±1.25μg/L、36.43±13.05 U/ml)(P<0.05).The expression of TSGF,SCC-Ag and CA125 in peripheral blood was positively correlated with the risk of recurrence within three years after treatment(γ=0.535,γ=0.329,γ=0.744,P<0.05)by Spearman correlation analysis.Further ROC analysis showed that the sensitivity,specificity and accuracy of TSGF,SCC-Ag and CA125 expression in cervical cancer were significantly higher than those in cervical cancer before and after chemotherapy.Conclusion The expression of TSGF,SCC-Ag and CA125 in peripheral blood of patients with early cervical cancer before chemotherapy can be used as one of the indicators of prognosis evaluation.

关 键 词：肿瘤特异性生长因子 糖类抗原-125 鳞状细胞癌抗原 Ⅰ期宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]