一种改良的癫痫放电脑电图监测方法  

An Improved Method for Electroencephalographic Detection of Epileptic Discharge

作　　者：施新泽 许琪[1] SHI Xinze;XU Qi(National Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing 100005,China)

机构地区：[1]中国医学科学院基础医学研究所北京协和医学院基础学院医学分子生物学国家重点实验室,北京100005

出　　处：《中国医学科学院学报》2019年第1期53-56,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81501131;81471325;31430048和81625008)~~

摘　　要：目的探究OpenBCI模块对小鼠癫痫放电的检测效果。方法选用8～12周龄C57BL/6J小鼠,分为对照组和癫痫模型组,建立海人酸诱导的小鼠癫痫模型,分别通过脑功能监护仪和OpenBCI模块监测其3周的脑电发作情况。结果脑电图数据显示,OpenBCI模块可以同时监测8只小鼠的发作情况,对小鼠的静息放电、棘波放电、癫痫大发作放电及随后的抑制期都有良好的记录效果。结论 OpenBCI模块成本相对低廉,数据占用量小,在常规的脑电监测上基本可以替代临床脑功能监护仪系统,具有广泛的应用价值。Objective To investigate the role of Open BCI module in the electroencephalographic( EEG)detection of epileptic discharge. Methods C57 BL/6 J mice aged 8-12 weeks were divided into two groups: the sham-operated group and kainic acid-induced epileptic group. Spontaneous seizures were monitored continuously for3 weeks either by EEG or by Open BCI. Results Up to 8 mice could be simultaneously monitored by Open BCI.Meanwhile,the module accurately recorded the resting discharge,EEG spikes,and seizures. Conclusion Compared with the conventional brain function monitoring system,the OpenBCI module has lower cost and data occupancy and thus may be applied in clinical settings.

关 键 词：癫痫 海人酸 脑电图检测 

分 类 号：R749.17[医药卫生—神经病学与精神病学]