同型半胱氨酸化与疾病  

Homocysteinylation and diseases

作　　者：章琳琪 范天睿 初明[1] ZHANG Lin-Qi;FAN Tian-Rui;CHU Ming(School of Basic Medicine, Peking University, Beijing 100191,China)

机构地区：[1]北京大学基础医学院,北京100191

出　　处：《生理科学进展》2019年第1期1-9,共9页Progress in Physiological Sciences

基　　金：北京市重点学科基础医学学科建设项目(BMU20110254);国家自然科学基金(81603119);北京市自然基金(7174316);国家基础科学人才培养基金(J1030831/J0108)资助课题

摘　　要：高同型半胱氨酸血症能引起多种疾病如动脉粥样硬化、恶性肿瘤、神经退行性疾病等。研究发现,同型半胱氨酸(homocysteine,Hcy)能诱导氧化应激、内质网应激、蛋白质聚集。然而,具体的分子机制还有待进一步研究。近年来,蛋白质的同型半胱氨酸化引起广泛关注,本文对Hcy的代谢途径、同型半胱氨酸化及对机体的影响予以综述。Hyperhomocysteinemia causes many diseases, such as atherosclerosis, malignant tumors, cataract and neurodegenerative diseases. Many studies have shown that homocysteine (Hcy) can cause oxidative stress, endoplasmic reticulum stress, protein aggregation. However, the underlying mechanisms require further investigation. In recent years, protein homocysteinylation has drawn widely attention. Here, we reviewed the metabolic pathways, homocysteinylation and the body effects of Hcy.

关 键 词：同型半胱氨酸 同型半胱氨酸硫内酯 同型半胱氨酸化 

分 类 号：R363[医药卫生—病理学]