老年期抑郁症患者认知功能及日常生活能力的相关研究  

Study on the cognitive function and daily living ability in elderly patients with depression

作　　者：那万秋[1] 陈海支[2] 李建华[2] 陈科[1] 薛亮 陈丽娟[2] NA Wanqiu;CHEN Haizhi;LI Jianhua;CHEN Ke;XUE Liang;CHEN Lijuan(Department of Geriatric Psychiatry,Huzhou Third People’s Hospital in Zhejiang Province,Huzhou 313000,China;Department of Psychiatry,Huzhou Third People’s Hospital in Zhejiang Province,Huzhou 313000,China)

机构地区：[1]浙江省湖州市第三人民医院老年精神科,浙江湖州313000 [2]浙江省湖州市第三人民医院精神科,浙江湖州313000

出　　处：《中国现代医生》2019年第3期61-63,67,共4页China Modern Doctor

基　　金：浙江省湖州市科技计划项目(2015GYB39);浙江省医药卫生科技计划(2017KY645)

摘　　要：目的探讨老年期抑郁症患者治疗前后认知功能、日常生活能力的变化。方法收集2015年7月～2017年7月的老年期抑郁症患者(观察组,艾司西酞普兰片治疗)及健康老年人(对照组),各80例,观察24周。对抑郁情况、认知功能及日常生活能力等进行研究。结果观察组治疗前MMSE、ADL评分均较对照组差(P<0.01);治疗后较前改善(P<0.01),但与对照组比较差异有统计学意义(P<0.01)。观察组治疗前MMSE评分与GDS、ADL均呈负相关(P<0.01);治疗24周末的MMSE及ADL变化值与GDS减分率均无相关性(P>0.05)。ADL变化值与MMSE变化值负相关(P<0.01)。结论急性期老年抑郁症患者存在认知功能及日常生活能力受损;治疗后也未完全恢复。Objective To investigate the changes of cognitive function and daily living ability in elderly patients with depression before and after treatment. Methods 80 patients with senile depression(observation group, treated by escitalopram tablets) and healthy elderly patients (control group) were collected from July 2015 to July 2017, and they were observed for 24 weeks. The depression, cognitive function and daily living ability were studied. Results The scores of MMSE and ADL in the observation group before treatment were worse than those in the control group(P<0.01);the improvement was improved after treatment (P<0.01), However, the difference was statistically significant compared with the control group(P<0.01). The MMSE scores in the observation group before treatment were negatively correlated with GDS and ADL(P<0.01);there was no correlation between MMSE and ADL change values and GDS reduction rate at the end of 24 weeks of treatment (P>0.05). The ADL change value was negatively correlated with the MMSE change value(P<0.01). Conclusion Patients with senile acute depression have impairment of cognitive function and daily living ability;it is not able to fully recover after treatment.

关 键 词：老年 抑郁症 认知功能 日常生活能力 

分 类 号：R749.4[医药卫生—神经病学与精神病学]