小梁切除术后行激光断线对眼压的影响和时机选择的相关性  

Clinic observation of effect and timing of laser suture lysis in reducing intraocular pressure after trabeculectomy

作　　者：胡红梅[1] 胡郑君 严吕霞[1] 徐峰 Hong-Mei Hu;Zheng-Jun Hu;Lyu-Xia Yan;Feng Xu(Department of Ophthalmology, Xiantao First People's Hospital Affiliated to Yangtze University, Xiantao 433000, Hubei Province, China;Department of Ophthalmology, Chinese Medicine Hospital of Xiantao, Xiantao 433000, Hubei Province, China)

机构地区：[1]长江大学附属仙桃市第一人民医院眼科,中国湖北省仙桃市433000 [2]中国湖北省仙桃市中医医院眼科,433000

出　　处：《国际眼科杂志》2019年第3期467-469,共3页International Eye Science

摘　　要：目的:评价小梁切除联合使用5-氟尿嘧啶术后行激光断线后的眼压变化,及其与激光断线时机的相关性。方法:选取我院行小梁切除联合使用5-氟尿嘧啶的原发性慢性闭角型青光眼患者60例60眼,根据其术后眼压情况(21mmHg为激光断线的目标眼压)行激光断线。根据术后至激光断线的时间,将患者分为三组:<2wk组、2～4wk组、>4wk组。随访观察激光断线前后的眼压情况。结果:三组患者激光断线前眼压无差异(P=0.999),激光断线即刻和激光断线后12wk,三组间眼压有差异(P<0.05)。激光断线2～4wk组中,74%患者可达到目标眼压。目标眼压达标率与激光断线时间点呈负相关(P_(trend)=0.069)。结论:小梁切除联合使用5-氟尿嘧啶术后2～4wk行激光断线是一种降低眼压安全、有效的方法。·AIM:To evaluate the changes in intraocular pressure(IOP)after laser suture lysis after trabeculectomy associated with 5-Fluoroaracil and the correlate the effect in relation to the time of laser suture lysis.·METHODS:Prospective interventional study of sixty eyes of sixty patients.Trabeculectomy associated with 5-Fluoroaracil was performed for 60 patients with glaucoma.Laser suture lysis was carried out according to the IOP of post trabeculectomy.21 mmHg was used as the cut off for the achievement of target IOP.According to the timing of laser suture lysis,patients post trabeculectomy were divided into three groups:<2 wk,2nd-4thwk and>4 wk.·RESULTS:The differences of IOP prelaser suture lysis showed no statistical significance among three groups(P=0.999).The difference of IOP following 12 wk post laser suture lysis showed significant statistical significance(P<0.05)among three groups.When laser suture lysis was performed during 2nd-4th week post trabeculectomy,28 patients(74%)achieved the target IOP.Target IOP achieved is negatively correlated to higher week of lysis(Ptrend=0.069).·CONCLUSION:Laser suture lysis during 2nd-4th week post trabeculectomy associated with 5-Fluoroaracil is an effective and safe technique for reducing IOP.

关 键 词：眼内压 激光断线 小梁切除术 5-氟尿嘧啶 

分 类 号：R779.6[医药卫生—眼科]