免疫功能正常无感染征象的脑曲霉菌感染患者1例并文献复习  

Cerebral aspergillosis in immunocompetent with no signs of infection——a case report and literature review

作　　者：张旭[1] 向凤 王辅林[2] 杜少静 黄德晖[1] 郎森阳[1] Zhang Xu;Xiang Feng;Wang Fulin;Du Shaojing;Huang Dehui;Lang Senyang(Department of Neurology,General Hospital of PLA,Beijing 100853,China;Department of Pathology,General Hospital of PLA,Beijing 100853,China)

机构地区：[1]解放军总医院神经内科,北京100853 [2]解放军总医院病理科,北京100853

出　　处：《临床荟萃》2019年第2期158-162,共5页Clinical Focus

摘　　要：目的报道1例免疫功能正常、无感染征象的患者脑内曲霉菌感染及其治疗经过,并进行文献复习。方法 1例初期诊断原发性中枢神经系统血管炎的脑内曲霉菌感染,病理活检证实曲霉菌感染。结果规律伏立康唑抗真菌治疗后,患者病情平稳,脑内感染病灶稳定。结论脑内曲霉菌感染表现多样,免疫功能正常、无感染征象、非局部播散的患者影像无特异性,临床工作中需提高对脑内曲霉菌感染的认识及警惕性有助于早期诊断、早期治疗,降低病死率。Objective To report a case of cerebral aspergillosis in immunocompetent with no signs of infection and corresponding treatment, then review the literature. Methods One patient of cerebral aspergillus infection in primary angiitis of the central nervous system was diagnosed by pathological biopsy. Results After the regular anti fungal treatment with voriconazole, the patient’s condition and the lesion in the brain were all stable. Conclusion There are various manifestations of aspergillus infection in the brain. The imaging of immunocompetent patient with no signs of infection and non local dissemination is not specific. It is necessary to improve the acknowledge and vigilance of cerebral aspergillosis contributing to early diagnosis, early treatment and reduce mortality.

关 键 词：中枢神经系统感染 曲霉菌属 伏立康唑 

分 类 号：R742.89[医药卫生—神经病学与精神病学]