对比玻璃酸钠与rb-bFGF治疗LASEK术后角膜上皮修复及敏感性恢复的作用  

Comparison of the effects between sodium hyaluronate and rb-bFGF in corneal epithelium repair and corneal sensitivity recovery after LASEK surgery

作　　者：杨琨 薛超[1] 金颖[1] 耿维莉[1] YANG Kun;XUE Chao;JIN Ying;GENG Wei-li(Tianjin Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, China)

机构地区：[1]天津市眼科医院天津医科大学眼科临床学院天津市眼科研究所天津市眼科学与视觉科学重点实验室,天津300020

出　　处：《基础医学与临床》2019年第3期396-399,共4页Basic and Clinical Medicine

摘　　要：目的对比玻璃酸钠滴眼液与重组牛碱性成纤维细胞生长因子(rb-bFGF)凝胶在准分子激光角膜上皮瓣下角膜磨镶术(LASEK)术后角膜上皮修复及敏感性恢复方面的作用。方法选取2017年5月至2018年8月在天津市眼科医院接受LASEK手术的患者60例(120只眼),随机分为2组,分别使用0.3%玻璃酸钠滴眼液及rb-bFGF眼用凝胶治疗3个月。于术后1周、1和3个月行泪液分泌实验(SIT)、泪膜破裂时间(BUT)、角膜上皮完整性评估以及角膜敏感性检查。结果术后两组的SIT和BUT随治疗时间逐渐恢复,至术后3个月时均大致恢复到正常水平。术后1月时,rb-bFGF组角膜上皮完全恢复正常眼数(53眼,88.3%)显著高于玻璃酸钠组(45眼,75.0%)(P<0.05)。术后3月,rb-bFGF组各方位的角膜敏感性显著高于玻璃酸钠组(P<0.05)。结论 0.3%玻璃酸钠及rb-bFGF均能有效缓解LASEK术后导致的干眼,但在角膜上皮修复和敏感性恢复方面rb-bFGF作用更显著。Objective To evaluate the effects of 0.3% sodium hyaluronate eye drops and recombinant bovine basic fibroblast growth factor (rb-bFGF) after LASEK surgery in corneal epithelium repair and corneal sensitivity recovery. Methods Prospective control study was carried out. A total of 60 patients (120 eyes) were divided into sodium hyaluronate group and rb-bFGF group, each group was administrated with 0.3% sodium hyaluronate or rb-bFGF after the surgery for 3 months, respectively. The examinations of Schirmer Ⅰ Test (SIT), tear film break-up time(BUT), corneal epithelium integrity evaluation and Cochet-Bonnet esthesiometer were performed in 1 week, 1 month and 3 months, respectively. Results After the surgery, the SIT and the BUT test were gradually recovered with treatment time and both returned to normal level approximately in 3 months. After 1 month, the corneal epithelium totally recovered cases in rb-bFGF group (53 eyes, 88.3%) were significant higher than that in the sodium hyaluronate group (45 eyes, 75.0%)( P <0.05). After 3 months, the corneal sensitivity in all the examination positions in the rb-bFGF group was significantly higher than the sodium hyaluronate group( P <0.05). Conclusions Both sodium hyaluronate and rb-bFGF have positive effects dry eye syndrome after LASEK surgery, however,rb-bFGF is more effective for corneal epithelium repair and corneal sensitivity recovery.

关 键 词：玻璃酸钠 重组牛碱性成纤维细胞生长因子 LASEK 角膜上皮修复 角膜敏感性 

分 类 号：R77[医药卫生—眼科]