人循环血免疫指数模型在结直肠癌预后的预测价值分析  

Prediction value of the circulating blood immune index in patients suffering from colorectal cancer

作　　者：贺文涛[1] HE Wen-tao(The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui)

机构地区：[1]安徽医科大学第一附属医院,安徽合肥230022

出　　处：《安徽卫生职业技术学院学报》2019年第1期23-25,共3页Journal of Anhui Health Vocational & Technical College

摘　　要：目的:探讨循环血免疫指数模型(IIM)对结直肠癌患者预后的预测价值。方法:分析某医院收治的125例结直肠癌手术患者的临床病理资料,建立IIM并行受试者工作特征曲线(ROC)分析,确定最佳截点值分组,继而行Kaplan-Meier分析和单因素及多因素Cox比例风险模型分析。结果:该组患者5年预后生存时间最佳截点为2.34和183,IIM比值与患者肿瘤分期、分化程度及淋巴细胞计数密切相关。术后高NLR组患者RFS和OS均低于低比值组(P<0.05),且高PLR组RFS和OS均明显低于低比值组(P<0.05)。肿瘤分期、术后化疗及IIM均为影响患者RFS和OS的独立危险因素。结论:高水平NLR/PLR与人结直肠癌预后不良相关,对预后具有较好的预测价值。Objective:To investigate the prediction value of circulating blood immune index in the prognosis of colorectal cancer.Methods:Clinicopathological data of colorectal cancer patients identified by pathology undergoing radical resection were analyzed retrospectively.A receiver operating characteristic(ROC)curve then constructed to the predictive abilities of survival prognosis and calculated the cut-off value,then the Kaplan-Meier method and Cox regression analysis were used.Results:The optimal value of NLR/PLR was calculated at 2.34 and 183.All patients with higher cancer stage,poor tumor differentiation and elevated lymphocyte were obviously associated with high NLR/PLR level,and the follow-up result indicated that OS and PFS of patients with higher NLR/PLR level had poorer OS and PFS(P<0.05).Advanced cancer stage,post-chemotherapy and IIM were independent risk factors for poor prognosis of patients with colorectal cancer.Conclusion:Pre-treatment high NLR/PLR level is associated with poor prognosis,which may be a valuable predictor for patients with colorectal cancer.

关 键 词：结直肠癌 中性粒细胞/淋巴细胞 血小板/淋巴细胞 

分 类 号：R735.37[医药卫生—肿瘤]