包埋法制备替米考星淀粉微球工艺的优化  

Optimization of Preparation Process of Tilmicosin Starch Microspheres by Embedding Method

作　　者：王丽[1] 陈洪轩[1] 常杰 吴宁鹏 杨小云[1] 张翠利[1] 班付国 WANG Li;CHEN Hong-xuan;CHANG Jie(Huanghe Science and Technology College,Zhengzhou,Henan 450000)

机构地区：[1]黄河科技学院,河南郑州450000 [2]河南省兽药饲料监察所,河南郑州450008

出　　处：《安徽农业科学》2019年第4期110-113,共4页Journal of Anhui Agricultural Sciences

基　　金：河南省创新型科技团队项目(预科人组[2017]1号)

摘　　要：[目的]研究替米考星淀粉微球的制备工艺。[方法]以可溶性淀粉为原料,以N,N’-亚甲基双丙烯酰胺为交联剂,以过硫酸钾和亚硫酸氢钠为引发剂,采用包埋法制备替米考星淀粉微球。以载药量和包封率为指标,通过正交试验,采用综合平衡法对替米考星淀粉微球的制备工艺进行优化,在扫描电子显微镜下观察替米考星交联微球的形貌及表面形态。[结果]替米考星淀粉微球的最佳制备工艺如下:替米考星0.02 g,可溶性淀粉4 g,交联剂(N,N’-亚甲基双丙烯酰胺)0.95 g,乳化剂(m_(Span80):m_(Tween80)=2∶1)0.75 g,反应时间1.5 h,在优化工艺参数下制得的替米考星淀粉微球载药量为1.63%,包封率为81.4%;微球大小分布均匀,外观圆整,表面粗糙多孔。[结论]该制备工艺可行,扩大了替米考星的应用,为替米考星的剂型改进提供了参考。[Objective] To study the preparation process of tilmicosin starch microspheres.[Method] With soluble starch as materials,N,N’-methylene-bis-acrylamide as cross-linking agent and potassium persulfate with sodiun bisulflte as initiator,tilmicosin starch microsphere was synthesized by using embedding method.The preparation process of tilmicosin starch microsphere was optimized by integrated balance method through the orthogonal experiment,with the drug loading and encapsulation rate as indicators.The morphology features and surface topography of tilmicosin starch microsphere were characterized by Quanta 250FEG scanning electron microscope.[Result]The optimum preparation process was as follows:the quantity of tilmicosin 0.02 g,soluble starch 4.0 g,N,N’-methylene-bis-acrylamide 0.95 g,surfactant ( m Span80 ∶ m Tween80 =2 ∶1)0.75 g,and the reaction time was 1.5 h.Under these optimized technology parameters,the drug loading and embedding ratio of tilmicosin starch microsphere were 1.63% and 81.4% respectively.The size of microspheres was uniform,the appearance was round and the surface was rough and porous.[Conclusion] The preparation process was feasible,which expanded the application of tilmicosin.Therefore this research provided references for the improvement of tilmicosin’s dosage forms.

关 键 词：替米考星 可溶性淀粉 包埋法 微球制备工艺 

分 类 号：S859.796[农业科学—临床兽医学]