紫杉醇联合卡培他滨对比奥沙利铂联合卡培他滨在胃癌术后辅助化疗中的临床研究  

Paclitaxel plus capecitabine compared with oxaliplatin combined with capecitabine in postoperative adjuvant chemotherapy for gastric cancer

作　　者：梁文昌 王俊生[1] 耿明飞[2] 周静[1] LIANG Wenchang;WANG Junsheng;GENG Mingfei;ZHOU Jing(Anyang tumor hospital,Henan455000,China)

机构地区：[1]安阳市肿瘤医院内科,455000 [2]安阳市肿瘤医院胸外科,455000

出　　处：《中国老年保健医学》2019年第1期60-63,共4页Chinese Journal of Geriatric Care

基　　金：国家自然科学基金资助项目(编号:2016ZXG9101006)

摘　　要：目的对比紫杉醇联合卡培他滨以及奥沙利铂联合卡培他滨在胃癌术后辅助化疗的临床疗效。方法回顾性分析我院2011年1月至2013年1月收治的105例胃癌根治术后行辅助化疗的患者,分为A组和B组,A组55例患者实施奥沙利铂联合卡培他滨方案行术后辅助化疗,B组50例患者实施紫杉醇联合卡培他滨方案行术后辅助化疗,观察两组患者无病生存期(DFS)、总生存期(OS)以及不良反应发生情况。结果 A组和B组患者1年、2年、3年和5年DFS率、OS率对比差异均无统计学意义(P> 0. 05); A组、B组DFS分别为(32. 3±2. 5)个月、(27. 1±2. 2)个月,对比差异无统计学意义(P>0. 05); A组、B组OS分别为(55. 7±3. 6)个月、(47. 4±3. 9)个月,对比差异无统计学意义(P> 0. 05);两组患者均无化疗相关性死亡;化疗不良反应多为Ⅰ～Ⅱ度,Ⅲ～Ⅳ度相对较少; B组脱发发生率显著高于A组,对比差异有统计学意义(P <0. 05); B组Ⅲ～Ⅳ度骨髓抑制发生率高于A组,但对比差异无统计学意义(P> 0. 05)。结论两种方案在胃癌术后辅助化疗中临床疗效相近,不良反应均可耐受,临床上可根据患者的年龄、体力状况及其他因素个体化选择化疗方案。Objective To compare the clinical efficacy of paclitaxel combined with capecitabine and oxaliplatin plus capecitabine in postoperative adjuvant chemotherapy for gastric cancer.Methods A retrospective analysis of 105 patients treated with adjuvant chemotherapy after radical gastrectomy in December January 2011~2013 was divided into group A and group B.55 patients in group A were treated with oxaliplatin combined with capecitabine,and 50 patients in group B were treated with paclitaxel combined with capecitabine for adjuvant chemotherapy,and two groups were observed.Disease-free survival(DFS),total survival(OS)and adverse reactions occurred.Results There was no significant difference in DFS and OS rates in group A and group B(P>0.05)in 1 and 3 years;DFS in group A and group B were(32.3+2.5)months and(27.1+2.2)months respectively,and there was no statistical significance(P>0.05);A and B groups were(55.7+3.6)months and(47.4+3.9)months respectively,and there was no statistical difference.The study significance(P>0.05);the two groups of patients had no chemotherapy related death;the chemotherapy adverse reactions were mostlyⅠtoⅡdegrees,and the degree ofⅢtoⅣwas relatively less;the incidence of hair loss in group B was significantly higher than that in group A,and the difference was statistically significant(P<0.05),and the incidence of bone marrow suppression in group B was higher than that in group A,but there was no significant difference in contrast between group B.(P>0.05).Conclusion The two schemes have similar clinical effects in postoperative adjuvant chemotherapy for gastric cancer,and the adverse reactions can be tolerated.The chemotherapy regimens can be selected according to the patient's age,physical condition and other factors.

关 键 词：紫杉醇 卡培他滨 奥沙利铂 胃癌 术后辅助化疗 

分 类 号：R735.2[医药卫生—肿瘤]