球周注射在多途径联合给药治疗糖尿病性眼肌麻痹中的效果  

The therapeutic effect of peribulbar injection in the treatment of diabetic ophthalmoplegia with multi-channel combined administration

作　　者：刘子瑶[1] 姚亮[1] 胡笳[1] 孙超[1] 廖丁莹 王建明[1] 郑玉萍[1] LIU Ziyao;YAO Liang;HU Jia;SUN Chao;LIAO Dingying;WANG Jianming;ZHENG Yuping(Department of Ophthalmology, the Second Affiliated Hospital of Xi′an Jiaotong University, Shaanxi Province, Xi′an 710004, China)

机构地区：[1]西安交通大学第二附属医院眼科,陕西西安710004

出　　处：《中国医药导报》2019年第6期102-104,108,共4页China Medical Herald

基　　金：陕西省重点研发计划项目(2017SF-162)

摘　　要：目的对比分析球周注射在多途径联合给药治疗糖尿病性眼肌麻痹中的效果。方法回顾性分析2010年6月～2016年4月在西安交通大学第二附属医院眼科就诊并明确诊断为糖尿病性眼肌麻痹的患者68例,按入院顺序分为两组,2010年6月～2013年5月收治的患者归为球周注射治疗组(A组)(n=34);2013年6月～2016年4月收治的患者归为常规治疗组(B组)(n=34),对两组临床疗效用SPSS软件进行统计学分析,比较两组治疗方法对患者患眼偏斜程度、睑裂高度、复视、眼球运动等指标恢复的影响。结果两组患者性别、年龄、糖尿病病程、糖化血红蛋白比例、发病时间等一般资料比较差异无统计学意义(P> 0.05)。治疗1周后及治疗2周后A组总有效率明显高于B组(P <0.05),但是截至研究终止即治疗3个月后,两组总有效率比较差异无统计学意义(P>0.05)。结论配合球周注射维生素B12、地塞米松可缩短病程,加速眼肌功能的恢复;但从远期疗效来看,是否配合球周注射,对疗效无明显影响。Objective To compare and analyze the effect of peribulbar injection in the treatment of diabetic ophthalmoplegia with multi-channel combined administration. Methods Sixty-eight patients with diabetic ophthalmoplegia diagnosed at the Second Affiliated Hospital of Xi'an Jiaotong University from June 2010 to April 2016 were divided into two groups according to the order of admission. Patients admitted from June 2010 to May 2013 were classified into the peribulbar injection treatment group (group A)(n = 34);patients admitted from June 2013 to April 2016 were classified into routine treatment group (group B)(n = 34). The clinical efficacy of the two groups was statistically analyzed by SPSS software. The effects of two treatment methods on the recovery of degree of eye deviation, palpebral fissure height, diplopia and eye movement were compared. Results There were no significant differences in sex, age, duration of diabetes, ratio of glycated hemoglobin and morbidity time between the two groups (P > 0.05). The total effective rate of group A was significantly higher than that of group B after 1 week and 2 weeks of treatment (P < 0.05), while there was no significant difference in the total effective rate between the two groups at the end of the study (3 months of treatment)(P > 0.05). Conclusion Vitamin B12 and Dexamethasone injection can shorten the course of disease and accelerate the recovery of eye muscle function. However, in terms of long-term curative effect, whether it is combined with peribulbar injection or not has no significant influence on the curative effect.

关 键 词：眼肌麻痹 球周注射 联合给药 疗效 

分 类 号：R77[医药卫生—眼科]