CRISPR/Cas系统在人眼相关疾病中的应用  

Application of CRISPR/Cas system in human eye diseases

作　　者：姜梦圆 刘红玲[1] Meng-Yuan Jiang;Hong-Ling Liu(Department of Ophthalmology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科,中国黑龙江省哈尔滨市150001

出　　处：《国际眼科杂志》2019年第2期232-235,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81301325)~~

摘　　要：CRISPR/Cas系统原是在细菌的免疫系统内发现的用来抵抗外源遗传物质(如噬菌体病毒)的一种防御系统。由于其精确的靶向功能,CRISPR/Cas系统被开发成一种高效的基因编辑工具,被广泛地应用于生命科学研究的各个领域,并取得了革命性的进展。本文回顾性研究相关文献中关于CRISPR/Cas系统在人眼相关疾病中的应用,并进行总结。The CRISPR/Cas system was a defense system originally found in bacterial immune system against exogenous genetic material(such as phage virus).With the precision in its targeting function,CRISPR/Cas system has been developed into a highly efficient genome-editing tool that has been widely used in various fields of life science research and has achieved revolutionary progress.This paper reviews the relevant literature on the application of the CRISPR/Cas system in human eye diseases.

关 键 词：CRISPR/Cas系统 基因编辑技术 眼科学 

分 类 号：R77[医药卫生—眼科]