软性角膜接触镜在翼状胬肉切除联合自体角膜缘干细胞移植术后的应用  

Application effect of soft corneal contact lens on corneal limbal stem cell transplantation in elderly patients with pterygium

作　　者：林海波 李雯霖 卓晓 何爱群 Hai-Bo Lin;Wen-Lin Li;Xiao Zhuo;Ai-Qun He(Department of Ophthalmology,Central Hospital of Longhua,Shenzhen 518110,Guangdong Province,China)

机构地区：[1]广东省深圳市龙华区中心医院眼科,中国518110

出　　处：《国际眼科杂志》2019年第2期329-331,共3页International Eye Science

基　　金：深圳市科技计划项目(No.CXZZ20140730164451016)~~

摘　　要：目的:探讨翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜的临床效果。。方法:选择单侧翼状胬肉患者90例90眼,按照随机数字表法分为两组:观察组45例45眼翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜,对照组45例45眼翼状胬肉切除联合自体角膜缘干细胞移植术后不应用软性角膜接触镜。对比两组患者角膜愈合时间,术后1、3、5、7d角膜刺激症状评分,术后24、48h两组患者疼痛程度(VAS评分),翼状胬肉复发率。结果:对照组角膜愈合时间(5. 38±1. 67d)长于观察组(3. 10±1. 12d);术后角膜刺激症状评分、VAS评分高于观察组,差异有统计学意义(P<0. 05);两组患者翼状胬肉复发率比较差异无统计学意义(P>0. 05)。结论:翼状胬肉切除联合自体角膜缘干细胞移植术后应用软性角膜接触镜可减少创面愈合时间,减轻术后角膜刺激症状,同时对胬肉复发率无影响。AIM:To investigate the clinical effects of soft corneal contact lens after excision of pterygium and limbal stem cell transplantation in elderly patients.METHODS:Totally 90 patients(90 eyes)with unilateral pterygium were divided into two groups according to the random number table method.The observation group(45 cases)were treated with soft corneal contact lens after corneal limbal autograft transplantation merely,45 cases of the control group were treated by autologous limbal stem cell transplantation.According to the data obtained from two groups of patients,the following indicators were compared:corneal healing time,symptom score of corneal irritation in 1d,3d,5d,7d after operation,postoperative 24h、48h,two groups of patients with pain(VAS score),the recurrence rate of pterygium.RESULTS:In control group,the corneal healing time(5.38±1.67d)was more than that of observation group(3.10±1.12d;P<0.05);Score of the corneal stimulation symptom and VAS after operation were higher than those of the control group(P<0.05),and the difference in recurrence of pterygium was not statistically significant(P >0.05).CONCLUSION:Autologous corneal stem cells combined with soft corneal contact lens in treatment of elderly patients with pterygium can reduce the healing time,and reduce the postoperative symptom of corneal irritation,meanwhile it has no effect on the recurrence rate of pterygium.

关 键 词：原发性单侧翼状胬肉 自体角膜缘干细胞移植术 翼状胬肉切除术 软性角膜接触镜 

分 类 号：R779.6[医药卫生—眼科]